-
methylphenidate
increase NE and dopamine and other catecholamine concentration in the synaptic cleft. ADHD, narcolepsy, appetite control
-
dextroaphetamine
- amphetamine
- increase release and inhibit reuptake of NE and dopamine and other catecholamines, to increase the concentration in the synaptic cleft. ADHD, narcolepsy, appetite control
-
methamphetamine
- amphetamine
- increase release and inhibit reuptake of NE and dopamine and other catecholamines, to increase the concentration in the synaptic cleft. ADHD, narcolepsy, appetite control
-
haloperidol
- antipsychotic (high-potency 1st gen)
- block D2 dopamine receptors to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. Schizophrenia (positive symptoms), psychosis, bipolar disorder, delirium, Tourettes, Huntington, OCD
- highly lipid soluble (take a long time to get out of the body), prolonged QT, hyperprolactinemia(galactorrhea, oligomenorrhea, gynecomastia) neuroleptic malignant syndrome(fever, autonomic instability, rigidity, myoglobinemia[treat with dantrolene, D2 agonists(bromocriptine)]), extrapyramidal(hours to days->acute dystonia, days to months->akathisia[restlessness] and parkinsonism[bradykinesia], months to years->tardive dyskinesia[orofacial chorea][treat with benztropine, diphenhydramine, benzodiazepines], (high-potency have more EPS effects than peripheral effects), peripheral effects(dry mouth, constipation[muscarinic blockade], orthostatic hypotension [alpha1 blockade], sedation[histamine blockade])
- try to fly high (trifluoperazine, fluphenazine, haloperidol, high potency)
- ADAPT to EPS (hours to days->Acute Dystonia, days to months->Akathisia[restlessness] and Parkinsonism, months to years->Tardive dyskinesia)
- Neuroleapin' on the FARM (neuroleptic malignant syndrome, fever, autonomic instability, rigidity, myoglobinemia)
-
trifluoperazine
- antipsychotic (high-potency 1st gen)
- block D2 dopamine receptors to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. Schizophrenia (positive symptoms), psychosis, bipolar disorder, delirium, Tourettes, Huntington, OCD
- highly lipid soluble (take a long time to get out of the body), prolonged QT, hyperprolactinemia(galactorrhea, oligomenorrhea, gynecomastia) neuroleptic malignant syndrome(fever, autonomic instability, rigidity, myoglobinemia[treat with dantrolene, D2 agonists(bromocriptine)]), extrapyramidal(hours to days->acute dystonia, days to months->akathisia[restlessness] and parkinsonism[bradykinesia], months to years->tardive dyskinesia[orofacial chorea][treat with benztropine, diphenhydramine, benzodiazepines], (high-potency have more EPS effects than peripheral effects), peripheral effects(dry mouth, constipation[muscarinic blockade], orthostatic hypotension [alpha1 blockade], sedation[histamine blockade])
- try to fly high (trifluoperazine, fluphenazine, haloperidol, high potency)
- ADAPT to EPS (hours to days->Acute Dystonia, days to months->Akathisia[restlessness] and Parkinsonism, months to years->Tardive dyskinesia)
- Neuroleapin' on the FARM (neuroleptic malignant syndrome, fever, autonomic instability, rigidity, myoglobinemia)
-
fluphenazine
- antipsychotic (high-potency 1st gen)
- block D2 dopamine receptors to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. Schizophrenia (positive symptoms), psychosis, bipolar disorder, delirium, Tourettes, Huntington, OCD
- highly lipid soluble (take a long time to get out of the body), prolonged QT, hyperprolactinemia(galactorrhea, oligomenorrhea, gynecomastia) neuroleptic malignant syndrome(fever, autonomic instability, rigidity, myoglobinemia[treat with dantrolene, D2 agonists(bromocriptine)]), extrapyramidal(hours to days->acute dystonia, days to months->akathisia[restlessness] and parkinsonism[bradykinesia], months to years->tardive dyskinesia[orofacial chorea][treat with benztropine, diphenhydramine, benzodiazepines], (high-potency have more EPS effects than peripheral effects), peripheral effects(dry mouth, constipation[muscarinic blockade], orthostatic hypotension [alpha1 blockade], sedation[histamine blockade])
- try to fly high (trifluoperazine, fluphenazine, haloperidol, high potency)
- ADAPT to EPS (hours to days->Acute Dystonia, days to months->Akathisia[restlessness] and Parkinsonism, months to years->Tardive dyskinesia)
- Neuroleapin' on the FARM (neuroleptic malignant syndrome, fever, autonomic instability, rigidity, myoglobinemia)
-
thioridazine
- antipsychotic (low-potency 1st gen)
- block D2 dopamine receptors to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. Schizophrenia (positive symptoms), psychosis, bipolar disorder, delirium, Tourettes, Huntington, OCD
- highly lipid soluble (take a long time to get out of the body), prolonged QT, hyperprolactinemia(galactorrhea, oligomenorrhea, gynecomastia), peripheral effects(dry mouth, constipation[muscarinic blockade], orthostatic hypotension [alpha1 blockade], sedation[histamine blockade])(low-potency have more peripheral effects than EPS), peripheral effects, extrapyramidal(hours to days->acute dystonia, days to months->akathisia[restlessness] and parkinsonism[bradykinesia], months to years->tardive dyskinesia[orofacial chorea][treat with benztropine, diphenhydramine, benzodiazepines])
- low thieving cheat (low potency, thioridazine, chlopromazine)
- ADAPT to EPS (hours to days->Acute Dystonia, days to months->Akathisia[restlessness] and Parkinsonism, months to years->Tardive dyskinesia)
- Neuroleapin' on the FARM (neuroleptic malignant syndrome, fever, autonomic instability, rigidity, myoglobinemia)
-
chlorpromazine
- antipsychotic (low-potency 1st gen)
- block D2 dopamine receptors to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. Schizophrenia (positive symptoms), psychosis, bipolar disorder, delirium, Tourettes, Huntington, OCD
- highly lipid soluble (take a long time to get out of the body), prolonged QT, hyperprolactinemia(galactorrhea, oligomenorrhea, gynecomastia), peripheral effects(dry mouth, constipation[muscarinic blockade], orthostatic hypotension [alpha1 blockade], sedation[histamine blockade])(low-potency have more peripheral effects than EPS), peripheral effects, extrapyramidal(hours to days->acute dystonia, days to months->akathisia[restlessness] and parkinsonism[bradykinesia], months to years->tardive dyskinesia[orofacial chorea][treat with benztropine, diphenhydramine, benzodiazepines])
- low thieving cheat (low potency, thioridazine, chlopromazine)
- ADAPT to EPS (hours to days->Acute Dystonia, days to months->Akathisia[restlessness] and Parkinsonism, months to years->Tardive dyskinesia)
- Neuroleapin' on the FARM (neuroleptic malignant syndrome, fever, autonomic instability, rigidity, myoglobinemia)
-
aripiprazole
- atypical antipsychotic
- dopamine D2 partial agonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
- prolonged QT interval, less EPS and anticholinergic side effects that 1st gen antipsychotics
-
asenapine
- atypical antipsychotic
- dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
- prolonged QT interval, less EPS and anticholinergic side effects that 1st gen antipsychotics
-
clozapine
- atypical antipsychotic
- dopamine D2 partial agonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, refractory schizophrenia(partial agonist is a unique mechanism) bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
- prolonged QT interval, agranulocytosis, weight gain, less EPS and anticholinergic side effects that 1st gen antipsychotics
- pining for weight gain (-pines cause metabolic syndrome)
-
iloperidone
- atypical antipsychotic
- dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
- prolonged QT interval, less EPS and anticholinergic side effects that 1st gen antipsychotics
-
lurasidone
- atypical antipsychotic
- dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
- prolonged QT interval, less EPS and anticholinergic side effects that 1st gen antipsychotics
-
olanapine
- atypical antipsychotic
- dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
- prolonged QT interval, weight gain, less EPS and anticholinergic side effects that 1st gen antipsychotics
- pining for weight gain (-pines cause metabolic syndrome)
-
paliperidone
- atypical antipsychotic
- dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
- prolonged QT interval, less EPS and anticholinergic side effects that 1st gen antipsychotics
-
quetiapine
- atypical antipsychotic
- dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
- prolonged QT interval, weight gain, less EPS and anticholinergic side effects that 1st gen antipsychotics
- pining for weight gain (-pines cause metabolic syndrome)
-
risperidone
- atypical antipsychotic
- dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
- prolonged QT interval, hyperprolactinemia(amenorrhea, galactorea, gynecomastia), less EPS and anticholinergic side effects that 1st gen antipsychotics
-
ziprasidone
- atypical antipsychotic
- dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
- prolonged QT interval, less EPS and anticholinergic side effects that 1st gen antipsychotics
-
lithium
- unkown mechanism. Mood stabilizer for bipolar disorder
- tremor, hypothyroidism, nephrogenic DI, Ebstein anomaly, narrow therapeutic window, renal excretion (thiazides cause Li toxicity)
- LI BI DI and I (lithium, bipolar, diabetes inspidus, hypothyroidism[iodine])
-
buspirone
- stimulates 5-HT(1A) receptors. Generalized anxiety disorder
- no sedation, addiction, or tolerance! Also doesn't interfere with alcohol like barbiturates and benzodiazepines do
- don't be anxious that the BUS will be ON time (anxiety, buspirone)
-
SSRIs
- fluoxetine, paroxetine, sertaline, citalopram
- 5-HT reuptake inhibition, increasing 5-HT levels in the cleft. Depression, GAD, panic disorder, OCD, bulimia, social anxiety disorder, PTSD, premature ejaculation, premenstrual dysphoric disorder
- GI distress, SIADH, sexual dysfunction, serotonin syndrome takes 4-8 weeks to have an effect, fewer adverse effects than TCAs
- sertain select citizens are paralyzed by the flu (sertaline, SSRIs, citalopram, paroxetine, fluoxetine)
-
fluoxetine (class)
- SSRI
- sertain select citizens are paralyzed by the flu (sertaline, SSRIs, citalopram, paroxetine, fluoxetine)
-
paroxetine (class)
- SSRI
- sertain select citizens are paralyzed by the flu (sertaline, SSRIs, citalopram, paroxetine, fluoxetine)
-
sertaline (class)
- SSRI
- sertain select citizens are paralyzed by the flu (sertaline, SSRIs, citalopram, paroxetine, fluoxetine)
-
citalopram (class)
- SSRI
- sertain select citizens are paralyzed by the flu (sertaline, SSRIs, citalopram, paroxetine, fluoxetine)
-
SNRIs
- venlafaxine, desvenlafaxine, duloxetine, levomilnacipran, milnacipran
- 5-HT and NE reuptake inhibition, increase serotonin and NE levels in the cleft. Depression, GAD, diabetic neuropathy
- HTN, stimulant effects(tachycardia, insomnia?), sedation, nausea, serotonin syndrome
- it's a SiN to venmo/fax millions to levorage ox duels and change desvtiny (SNRIs, venlafaxine, milnacipran, levomilnacipran, duloxetine, desvenlafaxine)
-
venlafaxine (class/special?)
- SNRI
- Depression, GAD, diabetic neuropathy, also for social anxiety disorder, panic disorder, PTSD, OCD
- it's a SiN to venmo/fax millions to levorage ox duels and change desvtiny (SNRIs, venlafaxine, milnacipran, levomilnacipran, duloxetine, desvenlafaxine)
-
milnnacipran (class/special?)
- SNRI
- Depression, GAD, diabetic neuropathy
- it's a SiN to venmo/fax millions to levorage ox duels and change desvtiny (SNRIs, venlafaxine, milnacipran, levomilnacipran, duloxetine, desvenlafaxine)
-
levomilnacipran (class/special?)
- SNRI
- Depression, GAD, diabetic neuropathy
- it's a SiN to venmo/fax millions to levorage ox duels and change desvtiny (SNRIs, venlafaxine, milnacipran, levomilnacipran, duloxetine, desvenlafaxine)
-
duloxetine (class/special?)
- SNRI
- Depression, GAD, diabetic neuropathy
- it's a SiN to venmo/fax millions to levorage ox duels and change desvtiny (SNRIs, venlafaxine, milnacipran, levomilnacipran, duloxetine, desvenlafaxine)
-
desvenlafaxine (class/special?)
- SNRI
- Depression, GAD, diabetic neuropathy
- it's a SiN to venmo/fax millions to levorage ox duels and change desvtiny (SNRIs, venlafaxine, milnacipran, levomilnacipran, duloxetine, desvenlafaxine)
-
TCAs
- amitriptyline, nortriptyline, imipramine, desipramine, clomipramine, doxepin, amoxapine
- 5-HT and NE reuptake inhibition, increase serotonin and NE levels in the cleft. Major depression, peripheral neuropathy, chronic pain, migraine prophylaxis
- sedation, postural hypotension(alpha1 blockade), tachycardia, urinary retention, dry mouth, hallucinations in elderly(anticholinergic, worse with amitriptaline, so use nortriptyline), arrhythmia(Na block, tx is NaHCO3), respiratory depression, fever
- amo doxins, I pray mine hasn't tripped a line, that would make be 3x more depressed (amoxapine, doxepin, -ipramines[imipramine, desipramine, clomipramine], -triptylines[nortriptylines, amitriptyline], TCAs)
-
amitriptyline (class/special?)
- TCA
- tachycardia, urinary retention, dry mouth, hallucinations in elderly(anticholinergic effects, worse with amitriptaline, so use nortriptyline)
-
nortriptyline (class/special?)
- TCA
- less tachycardia, urinary retention, dry mouth, hallucinations in elderly(anticholinergic, worse with amitriptaline, so use nortriptyline)
-
impramine (class/special?)
TCA
-
desipramine (class/special?)
TCA
-
clomipramine (class/special?)
- TCA
- OCD, major depression, peripheral neuropathy, chronic pain, migraine prophylaxis
-
doxepin (class/special?)
TCA
-
amoxapine (class/special?)
TCA
-
MAOI
- tranylcypromine, phenelzine, isocarboxazid, selegiline
- MAO inhibition in neurons increases levels of amines(NE, 5-HT, dopamine), to increase their levels in the cleft. Atypical depression, anxiety
- serotonin syndrome(contraindicated with SSRIs, TCAs, St. John's wort, meperidine, dextromethorphan, cheese, wine[tyramine][wait 2 weeks for clearance of MAOI]), CNS stimulation
- that Mao is so carazy savage that he puts trannys in a funnel (MAOB, isocarboxazid, selegiline, tranylcypromine, phenelzine)
-
isocarboxazid (class)
- MAOI
- that Mao is so carazy savage that he puts trannys in a funnel (MAOB, isocarboxazid, selegiline, tranylcypromine, phenelzine)
-
tranylcypromine (class)
- MAOI
- that Mao is so carazy savage that he puts trannys in a funnel (MAOB, isocarboxazid, selegiline, tranylcypromine, phenelzine)
-
phenelzine (class)
- MAOI
- that Mao is so carazy savage that he puts trannys in a funnel (MAOB, isocarboxazid, selegiline, tranylcypromine, phenelzine)
-
bupropion
- atypical antidepressant
- unknown mechanism, increases NE and dopamine levels in the cleft. Depression, smoking cessation
- stimulant effects (tachycardia, insomnia), headache, seizures in anorexic/bulimic patients, no sexual side effects
-
mirtazapine
- alpha 2 antagonist, increasing NE and 5-HT levels, but also a potent 5-HT(2), 5-HT(3), and H1 receptor antagonist. Depression
- sedation (may be good though), increased appetite (might be good), weight gain (appetite increase) (might be good though), dry mouth
-
trazodone
- blocks 5-HT2, alpha 1, and H1 receptors with weak 5-HT reuptake inhibition. Insomnia of depression (high doses needed for antidepressive effects)
- sedation, priapism, postural hypotension
- traZZZobone (trazodone, sedation/insomnia, priapism)
-
verenicline
- partial antagonist at nicotinic ACh receptor. Smoking cessation
- wacked out dreams
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