Hepatitis Viruses--General and Hep A

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  1. What is hepatitis?
    it is an inflammation of the liver; you  may or may not have an infection (ex: ethanol)
  2. What is hep caused by?
    a viral infection that may take you from healthy--> inflamed liver--> chronic--> cirrhosis--> possibly cancer

    the reason is because it can worsen other symtpoms
  3. How similar are Hep viruses?
    they are indistinguishable from clinical symptoms

    antigenic properties must be used to distinguish them
  4. Types of Hep
    • A and B are most common
    • - A: enteric; transmitted fecal-orally
    • - B: serum hep; not fecal-oral; transmitted through blood contact

    • C, D, and E are pretty major
    • - D needs B to be able to infection
    • --> D can replicate only in cells infected with hep B virus, since it borrows the hep B surface proteins to package and form an envelope around its own capsid

    • C is the most concerning right now
    • - incidence is going up; causes severity of disease
    • - originally called "non-A, non-B"
  5. Hep A is an __ that is transmitted __.
    • enterovirus
    • fecal orally
  6. Location of Hep A
    • in areas with poor sanitation
    • --> poses a potential and worldwide problem
  7. Virion
    Naked icosahedral capsid (T=1)

    linear + ssRNA with VPg covalently bound to the 5' end and a poly(A) tail bound to the 3' end
  8. Hepatitis A virus is a __ that causes __--> it has the same genome organization; same basic life cycle in how it is transmitted between hosts
    • picornavirus
    • acute liver disease
  9. How does Hep A enter the body?
    in throguh tainted water or food-> GI tract-> intestines-> crosses into blood-> anemia-> gets to liver-> out through bile and shed in stool
  10. Hep A is __ in terms of its presence in the environment.
    very stable
  11. Hep A does not __.
    inhibit host cell protein or RNA synthesis and does not produce observable cytopathic effects during infection of cells in culture
  12. Out of all viruses, with Hep A, you will have an __ infection. 

    Explain. 
    • acute but resolving 
    • the incubation period is a couple of weeks but nothing happens.

    • 2-6 weeks: shed in feces
    • 5 weeks: antibody response
    • months later: out of your system
  13. Out of all viruses, with Hep A, you will have an __ infection. 

    Explain. 
    • acute but resolving 
    • the incubation period is a couple of weeks but nothing happens.

    • 2-6 weeks: shed in feces
    • 5 weeks: antibody response
  14. How is Hep A spread?
    by direct contact with infected individual and by contamination of food or water
  15. What are the icteric symptoms of Hep A?
    hepatitis jaundice

    after a couple of weeks, its out of your system
  16. Icteric phase of Hep A?
    • incubation
    • prodromal: appearance of symptoms
    • icteric: jaundice
    • convalescent: resolution is low
  17. Treatments?
    • not many if you have the disease
    • none or few of us have had hepatitis. There are a number of inactivated vaccines available
  18. Vaccine series of Hep A
    similar to inactivated polio virus

    tend to be virus particles infected with chemicals so they are no longer infectious--> inactivated

    some are in tissue culture systems
  19. After we get polio under control, we can start working on Hep A. 

    In regards to its transmission, ?
    Hep A over here is attained through travel. It does not seem to be indigenous to the area
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ID
317953
Card Set
Hepatitis Viruses--General and Hep A
Description
test two
Updated
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