-
Norethindrone
- oral progestin
- taken daily
-
Copper IUD
- Among most effective contraception
- copper = spermicidal effect
- Adverse effects: ectopic pregnancy, uterine perforation, cramps, menstrual pain
-
Norgestrel
- oral progestin
- taken daily
- Also used as postcoital contraceptive (2-4x dose)
-
Medroxyprogesterone acetate
- IM progesterone injection
- 3 months
-
-
Progestins (adverse effects)
- headaches
- abnormal menstrual bleeding
- decreased bone density (unique to medroxyprogesterone IM injections)
-
Norethindrone and ethinyl estradiol
- progestin + estrogen contraceptive agent
- oral
- 21days on, 7 days off
- Adverse effects: nausea, headaches, cardiovascular effects (mostly in smokers 35 and older), decreased glucose tolerance, weight gain, hyperkalemia (unique to drospirenone)
-
Ulipristal
- Selective progesterone receptor modulator
- more effective than norgestrel
- oral, rx needed
- drug of choice in emergency rooms
- Acts as a progesterone receptor antagonist in granulosa cells
-
Mifepristone
- oral
- Progesterone receptor antagonist
- Induces abortion (if followed by oral prostaglandin E1)
- glucocorticoid antagonist (can be used to treat Cushing's and DMII)
-
Finasteride
5alpha reductase inhibitor
-
Dutasteride
5alpha reductase inhibitor
-
Flutamide
Androgen receptor antagonist
-
bicalutamide and nilutamide
androgen receptor antagonists
-
Ketoconazole, spironolactone, abiraterone
inhibitor of steroid synthesis
-
Gonadorelin
- Synthetic GnRH
- Can be used as agonist or antagonist (long-acting use)
- Antagonist effect: surpasses gonadotropin secretion - treats endometriosis and dysmenorrhea in women
-
Luprolide
- Injectable GnRH agonist
- Can be used as antagonist
-
Cetrorelix
- GnRH antagonist
- injectable
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