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natural habitat is water, soil, and decaying vegetation
Pseudomonas aeruginosa
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A strict aerobe found in dog ears
Pseudomonas aeruginosa
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Gram negative aerobe that causes pyogenic infections (wound, ear, eye, urinary and genital, abscesses)
Pseudomonas aeruginosa
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Causes liquefactive necrosis
Pseudomonas aeruginosa
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Virulence factors for Pseudomonas aeruginosa
- Pili - adherence
- capsule
- LPS
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Produces pyocyanin and fluorescein pigments
Pseudomonas aeruginosa
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Has a unique fruity odor
Pseudomonas aeruginosa
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Opportunistic pathogen that causes pyogenic infections
Pseudomonas aeruginosa
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Why should you do susceptibility testing for Pseudomonas aeruginosa?
It is very good at resistance mechanisms
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Antimicrobial selections for Pseudomonas aeruginosa
Aminoglycosides, quinolones, carbenicillin, 3rd generation cephalosporins
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Causes Glanders
Burkholderia mallei
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Reservoir host for Burkholderia mallei
infected equidae
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Three forms of Burkholderia mallei
nasal, pulmonary, cutaneous (farcy)
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Diagnosis of Burkholderia mallei
Mallein test - intradermopalebral injection or eye drops of the protein
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Is there a vaccine for Burkholderia mallei?
Nope
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How did they treat Burkholderia mallei in the polo ponies?
12 wks parenteral enrofloxacin and trimethoprim/sulfa followed by oral doxycycline
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This is a zoonotic organism that has a 50% fatality rate in treated humans
Burkholderia mallei
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Transmission of Burkholderia mallei
via respiratory tract
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Found in parts of Asia, Middle East, and Africa
Burkholderia mallei
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Causes Melioidosis
Burkholderia pseudomallei
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What animals are susceptible to Burkholderia pseudomallei
All mammals (including humans)
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What animals are susceptible to Burkholderia mallei
Horses, other solipeds (camels), cats, dogs, humans
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Forms tubercle-like nodules that break down to form ulcers
Burkholderia mallei
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Transmission of Burkholderia pseudomallei
inhalation or ingestion, through wounds
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This is an environmental organism found in tropical soils and water throughout Southeast asia and central Africa
Burkholderia pseudomallei
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Most common form of disease caused by Burkholderia pseudomallei
Pulmonary
-
This pathogen causes localized nodules/abscesses with fever and muscle aches
Burkholderia pseudomallei
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This organism causes septic shock in diabetics and renal insufficiency
Burkholderia pseudomallei
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Causes acute or chronic disseminated infection with visceral nodules to terminal septicemia
Burkholderia pseudomallei
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Reactivation can occur as much as 18 years after exposure
Burkholderia pseudomallei
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