CLS01 - Immune System Review

  1. CD4 vs CD8
    • CD4: helper T cells
    • CD8: cytotoxic T cells
  2. granulocytes vs agranulocytes (mononuclear cells)
    • granulocytes: neutrophils, eosinophils, basophils
    • agranulocytes: monocytes (macrophages), lymphocytes, dendritic cel
  3. granulocytes w/ basic description and function
    • neutrophils: phagocytosis, destruction of pathogens
    • eosinophis: red or pink cytoplasmic granules (eosin)
    • multicellular parasites
    • basophils/mast cells: blue cytoplasmic granules (methylene blue)
    • allergic reactions, parasites
  4. mononuclear cells w/ basic description and function
    • Single lobed nucleus, no visible granules
    • Monocytes: phagocytic, macrophages in tissue, act as APC for lymphocytes
    • Lymphocytes: move to lymph nodes after maturation
    • NK cells destroy virus infected and cancer cells
    • B & T involved in acquired immunity
  5. Dendritic cells w/ basic description and function
    • Tissue specific, found in many tissues
    • Active phagocytes
    • APCs for lymphocytes in nodes
  6. What are the pathways for complement activation?
    • Classical: C1 protein binds to antigen-antibody complex
    • Alternative: C3 protein binds to pathogen cell surface, activates C3 convertase
    • Lectin: MBL (mannose-binding lectin) binds to bacterial surfaces with mannans (a polysaccharide)
    • this complex binds to C2 and C4
  7. MHC I vs MHC II
    • MHC I: present on all nucleated cells, recognize proteins produced by cells
    • "self"
    • MHC II: present on APCs, role in activation of T cells
    • "antigen"
  8. myeloid vs lymphoid cell types
    • Myeloid: RBCs, neutrophils, eosinophils,basophils/mast cells, macrophages/monocytes, dendritic cells
    • Lymphoid: T lymphocytes, B lymphocytes, NK cells
  9. Basic antibody structure
    • Y shaped
    • 2 identical H chains
    • 2 identical L chain
    • Constant region (determines location, functional class)
    • Variable region (determines sp. epitope)
  10. Briefly describe the classes of antibodies
    • IgG: major circulating antibody
    • cross placenta
    • indicator of long-lasting immunity
    • IgM: pentamer
    • first to appear after B cell stimulation
    • short-lived
    • IgA: Dimer in mucosa
    • found in colostrum (mother's milk)
    • IgE: allergic reactions
    • effective against worms
    • IgD: receptor on B cell surface
    • role in regulation? (not much known)
Card Set
CLS01 - Immune System Review
CLS01 - Immune System Review