CLS01 - Ch3 Reading (B&S)

  1. Modes of transmission
    • Direct: comes in direct contact w/ microbial reservoir
    • Indirect: encounters vector or vehicle(fomite)
  2. What are the two major types of phagocytes? development? strategy for "attack"?
    • Neutrophils (PMNs/polymorphonuclear leukocytes): develop in marrow, circulate in blood/tissues, first cells to bacterial infection, 
    • Macrophages: develop in marrow and circulate as monocytes then transform in tissue, reside in specific organs waiting for encounters
  3. Components of inflammation w/ basic description
    • Phagocytes: ingest/destroy microorganisms
    • Complement system: chemotaxis, opsonization, kill gram-negative bacteria directly
    • coagulation system: attract phagocytes, increase blood/fluid flow, physically inhibits spread of microorganisms
    • cytokines (secreted proteins): enhance activities of many cells (specific and nonspecific response)
  4. Abbreviations for the two active areas of an Ab
    • Fab region: antigen binding site (V in the Y)
    • Fc region: phagocyte/complement binding site (I in the Y)
  5. What are the two general branches of the specific immune system? Cells involved?
    • Antibody-mediated immunity (humoral immunity): B lymphocytes mediated by helper T cells and cytokines
    • *note, B cells actually activate the T cells initially
    • Cell-mediated immunity (cellular immunity): cytotoxic T cellls activated by antigen-presenting cells
  6. pathogenicity vs virulence
    • Pathogenicity: likelihood of causing disease
    • Virulence: amount of damage if disease is caused
  7. signs vs symptoms
    • signs: measurable, physical
    • symptoms: described by patient
  8. active vs passive immunization
    • active: standard immunization
    • passive: anti-toxin style
Card Set
CLS01 - Ch3 Reading (B&S)
CLS01 - Ch3 Reading (B&S)