Virology Exam1

  1. Enveloped DNA viruses
    • Poxviridae
    • Iridoviridae
    • Asfarviridae
    • Herpesviridae
    • Hepadnaviridae
  2. Enveloped RNA
    • Retro
    • Paramyxo
    • Rhabdo
    • Filo
    • Borna
    • Orthomyxo
    • Bunya
    • Arena
    • Corona
    • Arteri
    • Toga
    • Flavi
  3. DNA viruses
    • Pox
    • Irido
    • Asfar
    • Herpes
    • Adeno
    • Polyoma
    • Papilloma
    • Hepadna
    • circo
    • parvo
    • anellovirus
  4. Two types of Equine Influenza virus
    H7N7, H3N8
  5. What determines pathogenicity of influenza viruses
    If HA is cleaved by host protease or not
  6. Four genera of Orthomyxoviridae, which one infects humans & animals?
    A, B, C, Thogotovirus

    A infects humans & animals
  7. Which subtypes are associated with HPAI?
    H5, H7
  8. Canine influenza came from
    Equine H3N8 virus
  9. Humans died from this Influenza virus
    Avian Influenza A (H5N1)
  10. Alphavirus is part of which family
  11. Genus for canine distemper
  12. Parainfluenza virus 3 Genus?
  13. This virus is widespread in cattle. Genus Respirovirus
    Parainfluenza 3
  14. BRSV
    Bovine Respiratory Syncytial Virus
  15. Associated with stress and shipping fever
    • PI 3
    • BRSV
  16. Genus is Pneumoniavirus
  17. What is the Genus for BRSV
  18. Causes airway inflammation in baby humans
  19. Genus Henipavirus, seen in horses
    Hendra virus
  20. Traced back to bat viruses (name the Genus)
  21. Found in humans connected to pig farms
    nipah virus
  22. Genome for Paramyxoviridae
    RNA, single stranded, negative sense
  23. Genus for Newcastle disease
  24. Genus for avian paramyxovirus 1 (2-10)
  25. Canine distemper is part of the _____ family
  26. Virulence factors for Paramyxoviridae
    HA and fusion proteins
  27. This virus has syncytia and intercytoplasmic inclusion bodies
  28. Sindbis virus family
  29. Togaviridae genome
    RNA positive sense
  30. Arboviruses are
    insect borne viruses
  31. Arboviruses that use Biological transmission
    EEE, WNV, ZiKa
  32. Equine encephalitis is in what family
  33. This virus is transmitted by mosquitos, birds and small mammals are reservoir hosts, and it has high viremia in horses
    Venezuelan Equine Encephalitis
  34. Genus Alphavirus, most fatal in humans
    Eastern Equine Encephalitis virus
  35. Flavivirus genome
    RNA, positive sense
  36. Has polyprotein translocation followed by cleavage
  37. Flaviviruses (5)
    • yellow fever virus
    • dengue virus
    • japanese encephalitis virus
    • west nile virus
  38. discovered in a zoo in NYC
    West nile virus
  39. In the Pestivirus genus
    • BVDV, MD
    • Border disease
    • classical swine fever virus
  40. This virus has 2 types with the same serotype
  41. This virus has 2 biotypes (CP and NCP)
  42. This virus is characterized by syncytium formation, intracytoplasmic & intranuclear inclusion bodies
  43. Causes syncytia and intracytoplasmic inclusions
  44. BRSV stands for
    bovine respiratory syncytial virus
  45. Equine encephalitis virus from infection to primary viremia
    • bite of arthropod vector & replication at site of entry
    • Spread through lymphatics 
    • Primary viremia
  46. When is equine encephalitis virus contagious?
    secondary viremia
  47. CNS infection steps of equine encephalitis
    • Vascular endothelium infected
    • passive transport across endothelial and basement membranes
    • transport by infected leukocytes
    • passage through areas of vascular permeability
    • invasion of brain parenchyma
  48. This virus has a polyprotein that is translocated and cleaved
  49. This virus family can have teratological effects
  50. Border disease is a type of
  51. How do cattle get infected with BVD?
    a persistently infected animal
  52. How do you control BVD, border disease
    • Test the herd and cull Ab- Ag+ animals
    • Vaccination
  53. Birds and swine are viremic hosts of this virus
    Japanese encephalitis
  54. West Nile Virus is in what Genera?
  55. Packaged proteins for Retroviridae
    • integrase
    • reverse transcriptase
    • protease
  56. Two subfamilies of Retroviridae
    Orthoretrovirinae, Spumoretrovirinae
  57. 3 types of retroviruses
    • Endogenous
    • Exogenous - replication competent
    • exogenous - replication defective
  58. The three genes in the Retroviridae genome
    • gag
    • pol
    • env
  59. What does OPPV stand for? Is it immunodeficiency or transforming?
    Ovine progressive pneumonia virus, immunodeficiency
  60. Avian leukosis virus is a rapid/slow transforming virus
  61. RSV stands for
    rous sarcoma virus
  62. Oncogene for RSV
  63. Equine Infectious Anemia is a
    immune mediated retrovirus
  64. Alpharetroviruses include
    • Avian leukosis
    • sarcoma viruses
  65. Genus of FeLV and feline sarcoma virus
  66. Lentiviruses include (5)
    • CAEV
    • FIV
    • HIV
    • EIA
    • SIV
  67. Genus for FIV
  68. Family, subfamily, and genus for EIA
    Retroviridae, Orthoretrovirinae, Lentivirus
  69. What is a spumavirus
    foamy virus
  70. Family, subfamily and Genus of foamy viruses
    Retroviridae, Spumoretrovirinae, Spumavirus
  71. Genus for myeloblastosis viruses
  72. oncogene for avian myeloblastosis
  73. oncogene for simian sarcoma virus
  74. oncogene for McDonough feline sarcoma virus
  75. an src mutation affects
    signal transduction
  76. myb mutation affects
    transcription factors
  77. sis mutation is
    growth factor like
  78. fms mutation affects
    growth factor receptors
  79. Horizontal transmission of Avian Leukosis virus results in
    transient viremia, leukemia rare
  80. Congenital infection of ALV results in
    chronic viremia, tolerance, leukemia
  81. congential transmission of ALV is through
    The egg
  82. Genetic transmission of ALV results in
    no viremia, no leukemia, latent
  83. 30% of cattle with Bovine Leukemia virus develop
    peristant leukosis
  84. Transmission of BLV (3)
    • Horizontal
    • Oral (milk to calves)
    • Vertical (placental)
  85. BLV has tropism for
    B lymphocytes
  86. The majority of cats infected with FeLV
    recover in 6 weeks
  87. How is FeLV transferred?
    • saliva
    • blood
    • transplacental
  88. Viral persistance of FeLV occurs in ____% of cats
  89. Predominant form of neoplasm in FeLV
  90. Other forms of neoplasm in FeLV besides lymphosarcoma
    • alimentary
    • thymic
    • multicentric
  91. This virus mutates in the body and infects progenitor cells
  92. If FeLV mutates and infects progenitor cells it can cause
    • Lymphoblastic leukemia
    • erythroleukemia
    • myelogenous leukemia
    • anemia
  93. Causes glomerular nephritis in cats
  94. A cat has chronic stomatitis & gingivitis. What should you test for?
  95. FIP is caused by immunosuppression of this virus
  96. This virus is transmitted with FeLV
    feline sarcoma virus
  97. FIV has tropism for
    CD4+ T cells
  98. FIV infects (cells)
    lymphocytes, monocytes, CD4+ T cells
  99. What is seen following a FIV infection
    initial lymphopenia
  100. Are Abs successful in neutralizing the FIV virus
  101. If a cat is FIV Ab positive, you can make two assumptions
    It is vaccinated or infected
  102. How do you diagnose FIV if you don't know a vaccine history
  103. A cat presents with recurrent fever, weight loss, poor hair coat, anemia, lymphadenopathy, and chronic gingivitis. What are you going to test for?
    FeLV and FIV
  104. The cat tests positive for FIV antibodies. What do you do next?
    PCR to look for the virus
  105. A horse presented with fever, anorexia, and weakness. You ran a blood test and found that it was severely anemic. It dropped dead, despite your efforts. On necropsy, you find petechial hemorrages on the mucosae. What virus is on your differential list?
    Equine Infectious Anemia
  106. Equine Infectious Anemia has tropism for
  107. what causes the severe anemia in EIA?
    immune-mediated lysis of RBCs with complement
  108. What does CAEV stand for?
    caprine arthritis encephalitis virus
  109. Transmission of CAEV
    • vertical (milk/placental)
    • iatrogenic
    • horizontal (saliva)
  110. Most common mode of transmission for CAEV
    vertical (milk, placental)
  111. Your client calls you because his goats gave birth about 3 months ago and now a few of the kids are developing neurological signs. What do you do next?
    • Serology screen the whole herd for CAEV
    • PCR testing on individuals that test positive
    • cull the ones that have a positive PCR test
  112. Visna-Maedi is also called
    Ovine progressive pnemonia virus
  113. What does Visna and Maedi represent
    • Visna - wasting
    • Maedi - progressive pneumonia
  114. This causes hard bag in sheep
  115. These Lentiviruses cause leukoencephalomyelitis in goats/sheep
    • OPP
    • CAEV
  116. Hog cholera is what kind of virus (family and genus)
    Flaviviridae, Pestivirus
Card Set
Virology Exam1