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Enveloped DNA viruses
- Poxviridae
- Iridoviridae
- Asfarviridae
- Herpesviridae
- Hepadnaviridae
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Enveloped RNA
- Retro
- Paramyxo
- Rhabdo
- Filo
- Borna
- Orthomyxo
- Bunya
- Arena
- Corona
- Arteri
- Toga
- Flavi
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DNA viruses
- Pox
- Irido
- Asfar
- Herpes
- Adeno
- Polyoma
- Papilloma
- Hepadna
- circo
- parvo
- anellovirus
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Two types of Equine Influenza virus
H7N7, H3N8
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What determines pathogenicity of influenza viruses
If HA is cleaved by host protease or not
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Four genera of Orthomyxoviridae, which one infects humans & animals?
A, B, C, Thogotovirus
A infects humans & animals
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Which subtypes are associated with HPAI?
H5, H7
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Canine influenza came from
Equine H3N8 virus
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Humans died from this Influenza virus
Avian Influenza A (H5N1)
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Alphavirus is part of which family
Togaviridae
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Genus for canine distemper
Morbillivirus
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Parainfluenza virus 3 Genus?
Respirovirus
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This virus is widespread in cattle. Genus Respirovirus
Parainfluenza 3
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BRSV
Bovine Respiratory Syncytial Virus
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Associated with stress and shipping fever
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Genus is Pneumoniavirus
BRSV
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What is the Genus for BRSV
Pneumoniavirus
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Causes airway inflammation in baby humans
BRSV
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Genus Henipavirus, seen in horses
Hendra virus
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Traced back to bat viruses (name the Genus)
Henipaviruses
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Found in humans connected to pig farms
nipah virus
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Genome for Paramyxoviridae
RNA, single stranded, negative sense
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Genus for Newcastle disease
Avulaviruses
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Genus for avian paramyxovirus 1 (2-10)
Avulavirus
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Canine distemper is part of the _____ family
Paramyxoviridae
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Virulence factors for Paramyxoviridae
HA and fusion proteins
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This virus has syncytia and intercytoplasmic inclusion bodies
BRSV
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Sindbis virus family
Togaviridae
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Togaviridae genome
RNA positive sense
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Arboviruses are
insect borne viruses
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Arboviruses that use Biological transmission
EEE, WNV, ZiKa
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Equine encephalitis is in what family
Togaviridae
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This virus is transmitted by mosquitos, birds and small mammals are reservoir hosts, and it has high viremia in horses
Venezuelan Equine Encephalitis
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Genus Alphavirus, most fatal in humans
Eastern Equine Encephalitis virus
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Flavivirus genome
RNA, positive sense
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Has polyprotein translocation followed by cleavage
Flaviviridae
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Flaviviruses (5)
- yellow fever virus
- dengue virus
- japanese encephalitis virus
- west nile virus
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discovered in a zoo in NYC
West nile virus
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In the Pestivirus genus
- BVDV, MD
- Border disease
- classical swine fever virus
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This virus has 2 types with the same serotype
BVDV
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This virus has 2 biotypes (CP and NCP)
BVDV
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This virus is characterized by syncytium formation, intracytoplasmic & intranuclear inclusion bodies
Paramyxoviridae
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Causes syncytia and intracytoplasmic inclusions
BRSV
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BRSV stands for
bovine respiratory syncytial virus
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Equine encephalitis virus from infection to primary viremia
- bite of arthropod vector & replication at site of entry
- Spread through lymphaticsÂ
- Primary viremia
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When is equine encephalitis virus contagious?
secondary viremia
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CNS infection steps of equine encephalitis
- Vascular endothelium infected
- passive transport across endothelial and basement membranes
- transport by infected leukocytes
- passage through areas of vascular permeability
- invasion of brain parenchyma
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This virus has a polyprotein that is translocated and cleaved
Flaviviridae
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This virus family can have teratological effects
Flaviviridae
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Border disease is a type of
Pestivirus
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How do cattle get infected with BVD?
a persistently infected animal
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How do you control BVD, border disease
- Test the herd and cull Ab- Ag+ animals
- Vaccination
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Birds and swine are viremic hosts of this virus
Japanese encephalitis
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West Nile Virus is in what Genera?
Flavivirus
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Packaged proteins for Retroviridae
- integrase
- reverse transcriptase
- protease
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Two subfamilies of Retroviridae
Orthoretrovirinae, Spumoretrovirinae
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3 types of retroviruses
- Endogenous
- Exogenous - replication competent
- exogenous - replication defective
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The three genes in the Retroviridae genome
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What does OPPV stand for? Is it immunodeficiency or transforming?
Ovine progressive pneumonia virus, immunodeficiency
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Avian leukosis virus is a rapid/slow transforming virus
slow
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RSV stands for
rous sarcoma virus
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Equine Infectious Anemia is a
immune mediated retrovirus
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Alpharetroviruses include
- Avian leukosis
- sarcoma viruses
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Genus of FeLV and feline sarcoma virus
Gammaretrovirus
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Family, subfamily, and genus for EIA
Retroviridae, Orthoretrovirinae, Lentivirus
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What is a spumavirus
foamy virus
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Family, subfamily and Genus of foamy viruses
Retroviridae, Spumoretrovirinae, Spumavirus
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Genus for myeloblastosis viruses
Alpharetrovirus
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oncogene for avian myeloblastosis
myb
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oncogene for simian sarcoma virus
sis
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oncogene for McDonough feline sarcoma virus
fms
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an src mutation affects
signal transduction
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myb mutation affects
transcription factors
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sis mutation is
growth factor like
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fms mutation affects
growth factor receptors
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Horizontal transmission of Avian Leukosis virus results in
transient viremia, leukemia rare
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Congenital infection of ALV results in
chronic viremia, tolerance, leukemia
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congential transmission of ALV is through
The egg
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Genetic transmission of ALV results in
no viremia, no leukemia, latent
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30% of cattle with Bovine Leukemia virus develop
peristant leukosis
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Transmission of BLV (3)
- Horizontal
- Oral (milk to calves)
- Vertical (placental)
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BLV has tropism for
B lymphocytes
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The majority of cats infected with FeLV
recover in 6 weeks
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How is FeLV transferred?
- saliva
- blood
- transplacental
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Viral persistance of FeLV occurs in ____% of cats
30%
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Predominant form of neoplasm in FeLV
lymphosarcoma
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Other forms of neoplasm in FeLV besides lymphosarcoma
- alimentary
- thymic
- multicentric
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This virus mutates in the body and infects progenitor cells
FeLV
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If FeLV mutates and infects progenitor cells it can cause
- Lymphoblastic leukemia
- erythroleukemia
- myelogenous leukemia
- anemia
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Causes glomerular nephritis in cats
FeLV
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A cat has chronic stomatitis & gingivitis. What should you test for?
FeLV
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FIP is caused by immunosuppression of this virus
FeLV
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This virus is transmitted with FeLV
feline sarcoma virus
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FIV has tropism for
CD4+ T cells
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FIV infects (cells)
lymphocytes, monocytes, CD4+ T cells
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What is seen following a FIV infection
initial lymphopenia
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Are Abs successful in neutralizing the FIV virus
NO
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If a cat is FIV Ab positive, you can make two assumptions
It is vaccinated or infected
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How do you diagnose FIV if you don't know a vaccine history
PCR
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A cat presents with recurrent fever, weight loss, poor hair coat, anemia, lymphadenopathy, and chronic gingivitis. What are you going to test for?
FeLV and FIV
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The cat tests positive for FIV antibodies. What do you do next?
PCR to look for the virus
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A horse presented with fever, anorexia, and weakness. You ran a blood test and found that it was severely anemic. It dropped dead, despite your efforts. On necropsy, you find petechial hemorrages on the mucosae. What virus is on your differential list?
Equine Infectious Anemia
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Equine Infectious Anemia has tropism for
macrophages
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what causes the severe anemia in EIA?
immune-mediated lysis of RBCs with complement
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What does CAEV stand for?
caprine arthritis encephalitis virus
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Transmission of CAEV
- vertical (milk/placental)
- iatrogenic
- horizontal (saliva)
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Most common mode of transmission for CAEV
vertical (milk, placental)
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Your client calls you because his goats gave birth about 3 months ago and now a few of the kids are developing neurological signs. What do you do next?
- Serology screen the whole herd for CAEV
- PCR testing on individuals that test positive
- cull the ones that have a positive PCR test
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Visna-Maedi is also called
Ovine progressive pnemonia virus
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What does Visna and Maedi represent
- Visna - wasting
- Maedi - progressive pneumonia
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This causes hard bag in sheep
OPP
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These Lentiviruses cause leukoencephalomyelitis in goats/sheep
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Hog cholera is what kind of virus (family and genus)
Flaviviridae, Pestivirus
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