Antiarrythmics

  1. Which of the following statements is true with regards to the general principle of antiarrhythmic therapy?




    B) Antiarrhythmics may precipitate life-threatening arrhythmia
  2. Which of the following drugs has a wide spectrum of ion channel blocking effects (ie, affecting IKr, IKs, INa)?




    D) Amiodarone
  3. Which of the following drugs is a class 1B antiarrhythmic agent?




    B) Lidocaine
  4. Which of the following therapies may prolong QT interval and cause life-threatening ventricular arrhythmia such as torsade de pointes?




    B) Sotalol
  5. Some drugs that are effective to treat supraventricular tachycardia (SVT) may worsen ventricular tachycardia (VT). Which of the following drugs should be used with caution in the treatment of ventricular tachycardia (VT)?




    A) Flecainide
  6. Some drugs that are effective to treat supraventricular tachycardia (SVT) may worsen ventricular tachycardia (VT). Which of the following drugs should be used with caution in the treatment of ventricular tachycardia (VT)?




    D) Verapamil
  7. Lidocaine produces:




    B) Use-dependent blockade in diseased or depolarized heart tissue
  8. All of the followings are concerns of amiodarone therapy Except:




    B) Precipitation of Torsade de Pointee
  9. Both lidocaine and amiodarone:




    A) Block Na channels (reduce INa)
  10. Adenosine activates A1 receptors and causes:




    B) K efflux and hyperpolarization of AV nodal cells
  11. Which of the following antiarrhythmic drugs is paired correctly with its mechanism of action?




    B) Amiodarone / reducing K currents and increasing refractory period
  12. Which of the following drugs may reduce the AV conduction?




    D) Adenosine
  13. Which of the following does not reduce the AV conduction?




    C) ACE inhibitors
  14. L-type Ca channel activity determines the amplitude of slow action potentials. The amplitude of action potentials affects the impulse conduction. Which of following ECG parameters will be increased after a patient taking verapamil or diltiazem?




    C) P-R interval
  15. Verapamil or diltiazem prolongs P-R interval due to:




    A) Depressing the action potential amplitude of atrioventricular node and slowing impulse conduction
  16. Verapamil shortens Q-T interval because it:




    D) Shortens the plateau phase of ventricular action potentials
  17. Beta blocker metoprolol shortens Q-T interval because it:




    A) Reduces action potential duration of ventricular cells
  18. Procainamide prolongs Q-T interval because it:




    B) Produces a metabolite N-acetylprocainamide (NAPA)
  19. Which of the following drugs has an extensive first pass metabolism?




    D) Lidocaine
  20. Which of the following class of drugs prolongs Q-T interval that may lead to Torsade De Pointes?




    C) Class I-A
  21. Which of the following beta blockers prolongs Q-T interval that may lead to Torsade De Pointes?




    C) Sotalol
  22. Which of the following beta blockers has class III antiarrhythmic drug action?




    D) Sotalol
  23. Which of the following beta blockers is the best choice for managing an arrhythmic episode during a surgical operation procedure?




    D) Esmolol
  24. Which of the following antiarrhythmic drugs reduces both pacemaker current and L-type ca current?




    B) Metoprolol
  25. Which of the following antiarrhythmic drugs has the least AV block effect?




    A) Lidocaine
  26. Which of the following antiarrhythmic drugs may produces reverse use-dependent action?




    C) Dofetilide
  27. Which of the following is a wanted pharmacological action of antiarrhythmic drugs




    C) Reducing intracellular Ca overload
  28. Which of the following is an unwanted pharmacological action of antiarrhythmic drugs?




    A) Enhancing EAD or DAD activity
  29. Which of the following are paired correctly?




    C) Ibutilide / Activation of slow sodium current
  30. Which of the following is not paired correctly?




    A) Dronedarone / disturbance of thyroxine metabolism
  31. Which of the following is not a wanted pharmacological action of antiarrhythmic drugs




    B) Reverse-use dependent action
  32. Which of the following statements is FALSE regarding antiarrhythmics




    D) They may increase the excitability of ventricular myocytes
Author
ebmalonzo
ID
316346
Card Set
Antiarrythmics
Description
IT 2 (Final): Antiarrythmics
Updated