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Biochem - Unit II - Peptide hormone, Purine
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Tyrosine kinase pathway
ligand binds and induces dimerization
autophosphorylation
activated
RTK recruits protein w/ SH2 domain
Grb2 binds to RTK
Grb2 binds to Sos
Sos binds to membrane G protein, Ras, converting Ras-GDP to Ras-GTP
Ras-GTP is active and leads to MAP kinase activation
activated MAP kinase translocate to nucleus and activate transcription factors
Identify basic structures of purines, nucleosides, and nucleotides.
5-member ring+6-member ring w/ 4 N in the rings
adenine
: 6-amino purine
guanine
: 2-amino-6-oxypurine
base+ribose/deoxyripurine->nucleoside
nucleoside+phosphate->nucleotide
Identify key relationships between glucose metabolism and purine biosynthesis.
Knowledge of how amino acids are used in AMP and GMP biosynthesis.
Understand degradation pathways of purines and their relationship to uric acid metabolism and gout
Author
akhan
ID
316303
Card Set
Biochem - Unit II - Peptide hormone, Purine
Description
Biochem - Unit II - Peptide hormone, Purine - Birge
Updated
2016-02-22T10:17:56Z
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