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MCB 161 Assignment 1
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What's the key idea?
See spike when there's two stimuli next to each other
What's the key reason for there not being a summation/broad window of opportunity when two EPSPs come together?
There's also IPSPs
Use a drug that blocks GABAa receptors that broadens window
Makes sense b/c now it's consistent w/ the duration of EPSP
Define jitter
Variability of spiking
Spikes at some delay
What does GABA antagonist do to jitter?
Expands jitter time
Jitter happens at more variable time
Without inhibition, what happens?
Window is broader and jitter is higher
Feed-forward inhibition is responsible for what?
Coincidence detection
?
Whole cell recording- cell-attach
Bicu abolishes GABA and gets rid of inhibitory curve
There's a delay btwn onset of excitation and inhibition (about 2 ms, very fast)
What's the reason for delay in onset of excitation and inhibition?
Inhibitory neuron
What's disynaptic inhibition?
When you block inhibition, inhibition is blocked (duh)
BUT when you block excitatory syanpse with NBQX, both excitation and inhibition goes away b/c excitatory neuron usually activates inhibitory synapse
What does it mean that a single stimuli to the excitatory neuron spikes the inhibitory neuron?
Strong synapse
Spike sufficient enough to spike inhibitory neuron
What's the basic message; what's the difference btwn inhibition on cell body and somewhere on dendrites?
Fast inhibition b/c closer to axon hillock
Slower thru dendrites
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Author
Mursizzle
ID
316131
Card Set
MCB 161 Assignment 1
Description
MCB 161 Assignment 1
Updated
2016-02-19T14:10:02Z
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