-
Decreases conduction velocity
- Class Ia
- Procainamide, Quinidine, Disopyramide
-
Shortens depolarization and QT interval
- Class Ib
- Lidocaine, Mexilitine
-
Prolongs repolarization
Class Ia & Ic
-
Prolongs QT; risk for TdP
Class Ia
-
Most potent Na+ channel blockade; depressive & pro-arrhythmic effects
- Class Ic
- Flecainide, Propafenone, Moricizine, Encainide
-
Used for ventricular arrhythmias, NOT effective for SVT
- Class Ib
- Lidocaine, Mexilitine
-
Anticholinergic effects
Class Ia
-
AEs primarily neurological
- Class Ib
- Lidocaine, Mexilitine
-
AKA beta-blockers.
Class II
-
Has a negative inotrope effect.
Class II
-
Class II slow ____ firing and conduction through the _______.
-
Which drugs in class II also have BB action?
- amidoarone
- Sotalol
- Dronaderone
-
Which class III drugs can cause Torsades de Pointe?
- Ibutilide
- Dofetilide
- (can be an AE of Sotalol)
-
Similar to amiodarone but less AEs
Dronaderone
-
______ has several CYP450 interactions including with Warfarin.
Amiodarone (increases INR)
-
How does amiodarone work?
- Na, K, Ca, α-, β-blocking,
- decreases AV conduction/SN function
-
How do class IV work?
- Affect depolarization via blockade of Ca++
- causing slowed SA firing &
- slowed conduction through AV node
-
Which CCB's are primarily used? Names?
- NonDHP
- Verapamil & Diltiazem
-
_____ cannot be used to treat ventricular arrhythmias.
Class IV
-
Major AEs of class IV.
- bradycardia,
- excessive AV block,
- heart failure, hypotension;
- constipation (verapamil)
|
|
