Parastiology- Therapeutics

  1. What are methods of prevention? (2)
    prevent exposure to limit disease, prophylactic treatment
  2. What are Benzimidazoles used for? (4 types of parasites, 2 life stages)
    nematodes, lungworms, cestodes, flukes; larvae, ova
  3. What is the mechanism of action of Benzimidazoles?
    binds beta-tubulin, disrupting microtubules--> disrupts cell functions
  4. What is an important pharmacokinetic characteristic of Benzimidazoles in ruminants?
    limited water solubility--> stays in rumen as suspension, binding to feed material--> gradually released into lower GI--> slow release [opposite is true in monogastric animals]
  5. What is the least toxic group of therapeutics?
    Benzimidazoles- very high safety index [exception- albendazole]
  6. What specific drugs are in the Benzimidazole group? (4)
    Fenbendazole, oxfendazole, albendazole, pro-benzimidazoles
  7. What is the respective rate of absorption of the different formulations of Benzimidazoles? What respective plasma concs do they result in?
    • liquid> paste> pelleted
    • liquid < paste< pelleted
  8. What is the difference between letting a cow nurse on the deworming gun versus putting it in the pharynx and administering it down the throat?
    • nursing- esophageal groove closes, drug bypasses rumen and goes right into the abomasum
    • pharynx- drug goes into rumen, sustained release
Card Set
Parastiology- Therapeutics
vetmed parasitology