-
Describe components of the blood.
- Blood
- plasam
- Erythrocytes
- Leukocytes
- Platelets
- . Buffy coat
- Hematocrit
-
After centrifuging, of the listed blood components, which contains the components of immune function?
Buffy coat (white blood cells)
-
What percentage of our blood is plasma?
- 55%
- Which of the formed elements is present in the greatest concentration?
- ERYTHROCYTES (45% OF WHOLE BLOOD)
-
Explain the functions of the blood?
- Transport
- Regulation
- Protection
-
THE FUNCTION OF TRANSPORT
- • Delivering O2 and
- nutrients to body cells
- • Transporting metabolic
- wastes to lungs and
- kidneys for elimination
- • Transporting hormones
- from endocrine organs to
- target organs
-
THE FUNCTION OF REGULATION
- • Maintaining body
- temperature by
- absorbing and
- distributing heat
- • Maintaining normal
- pH in body tissues.
- • Maintaining adequate
- fluid volume in
- circulatory system
-
THE FUNCTION OF PROTECTION
- Preventing blood
- loss
- – Plasma proteins and
- platelets initiate clot
- formation
- • Preventing infection
- – Antibodies
- – Complement
- proteins
- – WBC
-
Which of the following is a protective function of blood
preventing infection
-
Describe the characteristics of erythrocytes
- Biconcave shape
- >97% hemoglobin
- Major factor
- contributing to blood
- viscosity
-
Which of the following is a characteristic of a mature erythrocyte?
It has a biconcave disc shape
-
DESCRIBE THE FUNCTIONS OF ERYTHROCYTES?
- • RBCs dedicated to
- respiratory gas
- transport
- • Hemoglobin binds
- reversibly with
- oxygen
- • Normal values
- – Males - 13–18g/
- 100ml; Females - 12–
- 16 g/100ml
-
Which of the following is a function of erythrocytes?
to transport oxygen and carbon dioxide
-
What is the name of the protein found in erythrocytes that transports respiratory gases?
hemoglobin
-
What triggers erythropoietin (EPO) production to make new red blood cells?
reduced availability of oxygen
-
What part of the body does erythropoietin (EPO) target to increase erythropoiesis?
bone marrow
-
Each hemoglobin can transport
________ oxygen molecules.
4
-
Oxygen binds to the _______ portion of hemoglobin.
iron atom
-
Describe the of the different types of leukocytes?
-
CHARACTERISTICS OF LEUKOCYTE
- neutrophil : Multilobed nucleus, pale red and blue
- cytoplasmic granules.
- EOSINOPHIL: Bilobed nucleus, red
- cytoplasmic granules.
- basophil:Bilobed nucleus, purplish-black cytoplasmic granules'.
- Lymphocyte:Large spherical nucleus, thin rim of
- pale blue cytoplasm.
- MONOCYTE: Kidney-shaped nucleus, abundant pale blue cytoplasm.
- NEUTROPHIL: the most numerous type of white blood cell.
- eosinophil: has a role in killing parasitic worms
- basophil: bilobed nucleus and dark-staining cytoplasmic granules.
- lymphocyte:small agranulocyte with a lifespan that ranges from a few hours to decades.
- Monocyte:U or kidney shaped in the nucleus.
-
Two categories of leukocytes
- Granulocytes – Visible cytoplasmic granules,
- lobed nuclei, phagocogytic
- – Neutrophils, eosinophils, basophils
- Agranulocytes – No visible cytoplasmic
- granules, spherical or kidney-shaped nulcei
- – Lymphocytes, monocytes
-
An elevated neutrophil count would
be indicative of ________.
an acute bacterial infection
-
Antihistamines counter the actions of which white blood cells?
Basophils
-
DESCRIBE FUNCTIONS OF THE DIFFERENT TYPES OF LEUKOCYTES
Defense against disease
- neutrophil: phagocytize bacteria
- eosinophil:kills parasitic worms
- basophil: release histamine and heparin when activated
- Lymphocyte: makes B & T cells
- Monocyte:develop into macorphage tissues
-
Which type of leukocyte is responsible for antibody production?
lymphocytes
-
Identify the leukocytes in the figure in order.
neutrophil, eosinophil, basophil, lymphocyte, monocyte
-
Which granulated leukocyte is most likely to be active during a bacterial infection?
NEUTROPHIL
-
Understand how new blood is formed and where
-
how erythropoiesis is regulated
-
Describe the three steps of hemostasis
- Vascular spasm: Smooth muscle contracts,
- causing vasoconstriction.
- Platelet plug formation:Injury to lining of vessel exposes collagen fibers; platelets adhere.
- Coagulation: Fibrin forms a mesh that traps red blood cells and platelets,
- forming the clot.
-
Which of the following shows the correct sequence of hemostasis from start to end?
vascular spasm, platelet plug formation, coagulation
-
A positive feed back of hemostatis which stage?
Plateltet plug formation
-
Clotting stage:
Fibrin-Coagulation
-
The immediate response to blood vessel damage is a ________.
-
Why don't platelets form plugs in undamaged vessels?
-
only contact of platelets with exposed collagen fibers and von Willebrand factor causes them to be sticky and form plugs.
Describe the ABO blood typing system and
-
AB is considered to be the universal recipient.
-
A person who lacks agglutinogen A but has agglutinogen B would have blood type:
B
-
how blood type is determined
by antigen A or B
-
An individual who is blood type AB negative can.
receive any blood type in moderate amounts except that with the Rh antigen.
-
A person with type AB blood has
A and B antigens and neither anti-A nor anti-B antibodies.
-
What determines a person's ABO blood type?
the antigens found on the RBCs
-
A person with A+ blood has _______.
-
anti-B antibodies
- the A antigen on the surface of the red blood cells.
- Rh antigen on the surface of the red blood cells
- all of the above
-
would make antibodies to the A antigen but not the B antigen.
person with type B blood
-
would make antibodies to the B antigen but not the A antigen
person with type A blood
-
would have type A and B antigens
person with type AB blood
-
would make antibodies to the A and B antigens
type O
-
Type A blood cannot be given to people with type B blood.
-
A person with type B blood could receive blood from a person with either type B or type O blood
-
.A person with type O blood has _______.
neither A nor B agglutinogens
-
-
Understand why it’s important that donor and recipients be ‘matches’
-
A mismatch of blood types during a transfusion is dangerous because ________
preformed antibodies in the recipient's blood will bind and clump (agglutinate) the donated cells
-
-
Agglutinogens: an antigen that stimulates the production of an agglutinin.
Agranulocytes: lack granular cytoplasm and have round nuclei.
Anemia: – Blood has abnormally low O2-carrying capacity
Antibody:
Antigens
Buffy coat:contains leukocytes and platelets.
Erythrocytes: intracellular protein that binds oxygen and transports it, most abdunant, 250 million volume
Formed elements:blood cells and cell fragments, white blood cells:leukocytes, defense cell
red blood cells:erythrocytes
-most abundant cell type
-specialized for transporting oxygen
platelets: cell fragments: clotting
Granulocytes:a white blood cell with secretory granules in its cytoplasm, e.g., an eosinophil or a basophil.
Hematocrit:s the percentage of erythrocytes in a whole blood sample.
Hematopoiesis:is the process of creating new blood cells in the body.
Hemocytoblasts:the parent cell all formed elements arise from the same type of stem cell.
Hemoglobin:protein found in erythrocytes that transports respiratory gases
Hemostasis: stoppage of bleeding
lymphocytes:leukocyte is responsible for antibody production.
Plasma: 55% of whole blood, 90 water
Platelets: membrane-closed cytoplasmicn fragments: megakrocyte.
Universal donor: 0
Universal reciepent: type AB
A person with type B blood can only give blood to people of type AB and B blood.
incompatible transfusion:Donate type B blood to a recipient with type O blood.
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