Immunology Test 1

  1. Biologic activites of the Fc fragment of an IgG molecule include all of the following EXCEPT:

    A) Binding to an antigen
  2. Diagnostic laboratory techniques most frequently used for the visual microscopic detection of antigens in tissue sections include:

    C) Immunofluorescence
  3. Secretory IgA antibodies:

    D) Are the predominate immunoglobulin in saliva
  4. The affinity of an anitbody is the measure of:

    A) The strength of it binding to antigen
  5. The component on the T-cell that actually binds antigen is:

    E) A heterodimer of alpha and beta chains
  6. The first Ig synthesized in response to initial exposure to antigen:

    B) IgM
  7. Most important for protecting a new-born from bacteria:

    D) IgG
  8. Important in protecting against parasitic infections:

    C) IgE
  9. The major Ig in the globulin fraction of serum:

    B) IgG
  10. Can bind the highest number of antigenic determinants:

    E) IgM
  11. The major Ig produced in a memory response:

    D) IgG
  12. Role in B-cell maturation, but no known protective function:

    E) IgD
  13. MHC II proteins are typically found on which type of cell?

    D) Antigen presenting cells
  14. Which of the following is a primary lymphoid tissue?

    C) Thymus
  15. A hapten:

    A) Requires a carrier to initiate an immune response
  16. Adjuvants may be used to:

    D) Form a depot for the antigen, thereby enhancing the immune response of the antigen
  17. Which of the following cells is important in antigen processing and presentation?

    E) Langerhans cells
  18. Which of the following factors is secreted my macrophages to induce apoptosis?

    D) Tumor necrosis factor
  19. Generally taken into the cells by phagocytosis:

    A) Exogenous antigens
  20. Synthesized within the cell:

    A) Endogenous antigens
  21. Processed and expressed on surface of APC in MHC II molecules:

    A) Exogenous antigens
  22. Generally recognized by CD4+ cells:

    C) Exogenous antigens
  23. Generally recognized by CD8+ cells:

    C) Endogenous antigens
  24. Viral antigens:

    B) Endogenous antigens
  25. Bacteria:

    B) Exogenous antigens
  26. Cytokines are polypeptides produced in response to microbes and other antigens. All of the follow are true of cytokines EXCEPT:

    B) Actions are pleiotropic in that many cytokines have the same effect
  27. Which of the following is not involved in innate immunity?

    D) Antibody
  28. Which of the following are characteristic of serum IgM molecules?

    1. Contains 5 monomeric Ig molecules
    2. J chain
    3. mu heavy chains
    4. Can bind to more than 2 antigen molecules
    5. Secretory component

    A) 1, 2, 3, 4
  29. All are required in the alternative pathway of complement activation EXCEPT:

    A) C1, C2, C4
  30. Which Ig is the best agglutinin?

    B) IgM
  31. Which of the following is an example of natural passive immunity?

    E) SIgA in breast milk
  32. Which of the following is most important in the specific immune response to intracellular bacteria?

    E) T cells
  33. All of the following are true of T-independent antigens EXCEPT:

    D) Induce immunologic memory
  34. Mechanisms for antibacterial immunity include all of the following EXCEPT:

    A) Cytotoxic T cell bacteriolysis
  35. Defects in the complement system could result in:

    B) Impaired elimination of microbial antigens and circulating immune complexes
  36. Anaphylatoxin activity is associated with:

    B) C3a and C3b
  37. Stimulates the production of IFN-g by NK cells and T cells:

    A) IL-12
  38. Stimulates proliferation of plasma cells:

    A) IL-6
  39. Inhibits IL-12 and TNF production:

    A) IL-10
  40. Stimulates isotype switching to IgE:

    D) IL-4
  41. Promotes differentiation of TH1 cells:

    C) IL-12
  42. Inhibits differentiation of TH2 cells:

    E) IFN-g
  43. Stimulates development of TH2 cells from naive CD4+ cells:

    B) IL-4
  44. Stimulates expression of MHC molecules on APCs:

    B) IFN-g
  45. Asthma is an example of:

    E) an IgE mediated syndrome
  46. All of the following have specific receptors for antigen EXCEPT:

    B) NK cells
  47. Active immunization can be induced by all of the following except:

    A) Antitoxins
  48. Type II hypersensitivity:

    E) Results from antibody dependent lysis
  49. The immunogenicity of a molecule is influenced by all of the following EXCEPT:

    E) Surface charge
  50. If self-reacting T-cell clones are not surpressed, and individual may develop:

    B) Autoimmune disease
  51. An antiviral state is induced by:

    E) Type I interferons
  52. All of the following are true EXCEPT:

    B) Antigens generally have only one antigenic determinant
  53. Major component of mast cell granules:

    A) Histamine
  54. Control mechanism for type I hypersensitivity:

    C) ECF-A
  55. Effects similar to histamine:

    B) Serotonin
  56. Secondary mediator of type I hypersensitivity leading to prolonged smooth muscle cell contraction:

    E) SRS-A
  57. Hypersensitivity- Skin testing:

    D) Type IV
  58. Hypersensitivity- chronic hepatitis B infection:

    B) Type III
  59. Hypersensitivity- ADCC:

    B) Type II
  60. Hypersensitivity- transfusion reactions:

    C) Type II
  61. Hypersensitivity- epinephrine to combat systemic anaphylaxis:

    C) Type I
  62. Hypersensitivity- mononuclear cell infiltrate:

    D) Type IV
  63. Hypersensitivity- poison ivy:

    C) Type IV
  64. All of the following are true of immunologic tolerance EXCEPT:

    A) Induced more readily in mature lymphocytes
  65. X-linked agammaglobulinanemia is due to:

    B) Defective pre-B cell maturation
  66. Which of the following results from the build-up of toxic metabolites in T cells due to the absence of key enzymes?

    B) SCID
  67. beta2-microglobulin is a part of:

    D) MHC I
Card Set
Immunology Test 1
All MC questions from test 1