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PHRD7095 PTX7 Lecture 12 - Molecular Targets in Cancer (doses & t1/2 ONLY)
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tamoxifen dosing
20mg po QD
tamoxifen t1/2
7-14 days
anastrozole dosing
1mg po qd
anastrozole t1/2
2 days
letrozole dosing
2.5mg po qd
letrozole t1/2
2 days
exemestane dosing
25mg po qd
exemestane t1/2
1 day
traztuzumab dosing
LD
: 4mg/kg IV over 90min
MD
: 2mg/kg IV weekly OR 6mg/kg IV q3wk
traztuzumab t1/2
6 (2mg/kg MD)or 16 days (6mg/kg MD)
bicalutamide dosing
50mg po qd
bicalutamide t1/2
7 days
enzalutamide dosing
160mg po qd
enzalutamide t1/2
6-8 days
abiraterone dosing
1000mg po qd
+ prednisone 5mg BID
abiraterone t1/2
12 hours
bevacizumab dosing (colon & lung)
colon
: 5, 7.5, or 10mg/kg
lung
: 15mg/kg
IV over 90min on an every 2-3week sched
bevacizumab t1/2
20 days
cetuximab dosing
LD
: 400mg/m2 IV over 90min
MD
: 250mg/m2 IV weekly
BSA equation
cetixumab t1/2
5 days
erlotinib dosing
150mg po qd
erlotinib t1/2
1-1.5 days
afatinib dosing
40mg po qd
afatinib t1/2
37 hours
crizotinib dosing
250mg po bid
crizotinib t1/2
42 hours
ceritinib dosing
750mg po qd
ceritinib t1/2
42 hours
vemurafenib dosing
960mg po bid
vemurafenib t1/2
57 hours
dabrafenib dosing
150mg po bid
dabrafenib t1/2
parent
: 8 hrs
active metab
: 10 & 21 hrs
trametinib dosing
2mg po qd
trametinib t1/2
4-5 days
ipilimumab dosing
3mg/kg over 90min q3wks (4 total doses)
ipilimumab t1/2
15 days
pembrolizumab dosing
2mg/kg IV over 30min q3wks
pembrolizumab t1/2
26 days
nivolimumab dosing
3mg/kg over 60min q2wks
nivolimumab t1/2
26 days
Author
daynuhmay
ID
310131
Card Set
PHRD7095 PTX7 Lecture 12 - Molecular Targets in Cancer (doses & t1/2 ONLY)
Description
cancer
Updated
2015-10-23T07:45:38Z
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