CIDP3

• spinal root 
• finding during autopsy that spinal roots had more pathology than distal parts

• create contrast during MRI, b/c it affects the relaxation times of protons
• MRI measures relaxation times for protons
• can pas blood brain barrier, when barrier is compromised as in MS
• affect water (a lot of protons)
• Water protons in different tissues have different T1 values, which is one of the main sources of contrast in MR images.

ulnar nerve

• put sending electrode in middle of arm, place receiving electrode on palm (M-wave)
• F-wave is created when the signal goes up and then comes down

• CD4, CD8,
• lymphocytes and MHC on Schwann cells, lesions in CIDP
• CD8 T cells become toxic when going after antigen on S.C, then destroy S.C

• nodes and paranodes
• GBS, affect Na+ channels.

• NF155 (paranodal regions between terminal loops and axonlemma)
• CASPR-2
• contactin

• contactin, NF, CASPR
• NrCAM is SC protein

• PLP (CNS)
• P0 (PNS)
• PMP22
• connexin

• rabbit, animal model of CIDP
• chronic relapsing EAN
• injected galactocerebroside, got galactocerebroside antibody which caused conduction block and demyelination
• not implicated in humans

affected Na channels, conduction block

full recovery is more challenging

no controlled studies, doesn't have proven efficacy

broad size of action potential

intersection of nerves

• sural nerve: has onion bulbs and few myelination
• plexus: only at death, hypertrophy, small amount of myelination.

• couldn't breath (hospitalized 3-4 times, had to have another central line)
• hooked up to a smaller machine than apheresis
• slurred speech
• received a higher infusion and head hurt so much that she vomited

to get walker, and canes

• didn't write anything of consequence,
• when all her friends graduated

also took steroids

• mood disorder and depression
• mania, weakness and fatigue 
• painful hips and shoulders, porous bones
• premature aging of the body

from dublin, ireland, wrote on online forum, wore leg brace had CIDP looking for young adults with it

• reduction in bone weight
• bones are weak and brittle

• adrenal suppression (no adrenaline, which is bad when you need surgery like in Sarah's abdominal surgery)
• heart not working well
• weaken ability of body to fight infections
• given steroid over and over (steroid induced psychosis)
• british soldiers (blood) and revolutionary ones (antibodies)
• screaming, full of adrenaline

• went to neurologist, thinking it was CIDP again, but it was viral syndrome
• yelled and stayed in bed for 5 months

• prayed with schizophrenic and poor woman with sick son
• everyone was treated as equals, on their final descent, needed to radiate mercy

• painted her face blue with marker
• naked, not allowed food unless she left the room, but she didn't leave room
• ECT (electroconvulsive therapy to reverse mental problems)

loading new software and manually reopening and reserving each one of her files

her disease had been in remission for 7 years

• stop taking steroids
• no bracelet
• plastic surgery as last thing to rid scars on her chest

• march 1995 diagnosed
• line pulled may 1996
• recovered from last acute CIDP relapse nov. 1999
• recovery from severe depression march 2004

treat hypomania, mania

• problem from CIDP to drinking
• sobriety afterward made her feel better than ever

sarah visits, who has CIDP

mine and every else's

motor and sensory

located are nodes of rangier, disrupt the sodium channel distribution, hence axonal damage

at the internode (not normally palmitoylated)

• non palmitoylated 
• antigangliosides antibodies cause axonal GBS

acute inflammatory demyelinating polyneuropathy

• up
• in the study, SNAP was recorded on the caudal (near tail) nerve, while stimulating was at the tail

stimulating needle electrode at the hip (proximal) or knee (distal) and recording was at the gastrocnemius muscle (back part of lower leg)

detecting antigens in tissue section with antibody binding.

• weakness of voluntary movement 
• used to determine clinical score in rats

• fight viruses and enact immune response
• lumph nodes removed from rats

• used as negative control in experiment b/c it is the main protein in CNS
• ConA was used as positive control, gives rise to T cells

degeneration/regeneration of axon or myelin

from lower spine to foot, largest single nerve

intact axons

• Interleukin 17 is a cytokine that acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation
• comes from immune cell

• no antigen, injected with CFA
• noninjected
• injected S-palm
• injected with P0

complete freund adjuvant, bacteria attracts macrophages and cells in injection site to increase immune response (long lasting antibody responses)

• age/gender matched clinical studies
• combine different studies into one to directly compare

• IVIg 
• plasma exchange
• immunosuppressant (no controlled trials, azathioprine doesn't have proven efficacy)
• Mab (monoclonal antibody)

• for panic attacks gave her too much
• highly addictive

extremely active

• sluggish, can't produce cortisol
• acne, weight gain, depression, maniac, hallucination (demerol used to calm Sarah down)

euphoria, irritability