Zoonotic2- Malaria/Chagas

  1. The organism causing the most severe malaria is _____________; the one causing the most common malaria is ______________.
    Plasmodium falciparum; Plasmodium vivax
  2. What is the vector for malaria-causing Plasmodium?
    female Anopheles mosquito
  3. The ____________ is picked up by Anopheles mosquito during blood meal; the ___________ is dropped off to the next host.
    gametocyte; sporozoite
  4. In the human host, Plasmodium travels to the _________ to grow and multiply; after the incubation period, it enters _________; parasites and toxins are freed when _______________.
    liver; RBCs; RBCs are ruptured
  5. In the insect vector, Plasmodium grows and matures during a __________ incubation period; then, it migrates to the ___________.
    10-21 day; salivary gland
  6. Death from malaria is...
    preventable with treatment.
  7. With uncomplicated malaria, the 3 stages include __(3)__ and last about ________ every second or third day.
    cold stage, hot stage, sweating stage; 6-10 hours
  8. What are the components of severe malaria? (4)
    neurologic signs, severe anemia, hemoglobinuria, pulmonary edema
  9. Severe malaria, associated with ____________, occurs most commonly in __(3)__.
    P. falciparum; immunologically naive, children, and pregnant
  10. Malaria relapses are associated with __(2)__; they result from...
    P. vivax and P. ovale; reactivation of dormant liver stage.
  11. How do prophylactic antimalarial drugs work?
    do not prevent initial infection, prevent development of parasite in blood
  12. Which species of malaria is zoonotic, and what is its usual host?
    Plasmodium knowlesi- macaques in SE Asia
  13. What is the etiologic agent of Chagas disease?
    Trypanosoma cruzi
  14. What is the vector for Chagas disease?
    Tritomine insect (kissing bug)
  15. The sylvatic life cycle of T. cruzi occurs in __(3)__; it is commonly/rarely a source of human infection.
    southern US, Central and South America; rarely
  16. The domestic life cycle of T. cruzi is typically associated with __________; it is commonly/rarely a source of human infection.
    substandard living conditions; commonly
  17. Describe the vector transmission of T. cruzi.
    infected insect takes blood meal and defecates near the bite wound; scratching inoculates wound or brings parasite to mucous membrane
  18. What are the possible modes of transmission of T. cruzi? (4)
    vector-borne, food-borne, iatrogenic (blood or organ transfusion), transplacental
  19. T. cruzi develops in the vector for _________, before it migrates to the ___________ and becomes infective.
    2-4 weeks; hindgut
  20. What are the phases of Chagas disease in humans? Describe them. (3)
    • acute phase- asymptomatic/ mild signs
    • intermediate phase- asymptomatic long-term
    • chronic phase- cardiovascular disease
  21. What is Roma├▒a's sign?
    unilateral periorbital swelling associated with Chagas disease
  22. Describe Chagas disease in dogs.
    similar to people- acute and chronic phase; first sign may be sudden death; cardiomegaly
Card Set
Zoonotic2- Malaria/Chagas
vetmed zoonotic2