MICHAELIS-MENTON EQUATION
BEST TO THINK OF THE MICHAELIS-MENTON EQUATION IN TERMS OF THE ENZYME-SUBSTRATE COMPLEX (E-S)
Vo = Vmax [S] / ([S] + Km)
MICHAELIS MENTON CONSTANT, KM, IS (K2+K3)/K1
THIS CONSTANT IS A MEASURE OF THE BREAKDOWN, OVER THE FORMATION OF, THE ENZYME-SUBSTRATE COMPLEX
SO, HIGH KM INDICATES HIGH RATE OF BREAKDOWN OF E-S, EITHER INTO THE PRODUCT OR BACK TO THE SUBSTRATE.
LOW KM INDICATES HIGH RATE OF E-S FORMATION OF ENZYME AND SUBSTRATE.
THE MORE SUBSTRATE, THE FASTER THE INITIAL VELOCITY.