The flashcards below were created by user
jdwein39
on FreezingBlue Flashcards.
-
Nitric Oxide mechanism
In vascular smooth muscle, NO binds to guanylyl cyclase, increasing cGMP, which mediates vasodilation
-
Nitroglycerin is used to treat _____
angina
-
Phosphodiesterase type 5
- Breaks down cGMP
- PDE5 inhibitors include Viagra, Levitra, Cialis
-
Why should you not take Viagra while on nitroglycerin?
- Nitroglycerin is converted to NO, which stimulates cGMP production
- PDE5 inhibitors like Viagra inhibit enzyme that breaks down cGMP
- So, too much cGMP
-
CCR5
- GPCR that is important for eliminating foreign agents, but is also a receptor that HIV can bind to in order to infect a cell
- Double-edged sword
-
SMADs
Molecules that are phosphorylated and activated by serine/threonine kinase receptors (like TGFβ receptor); they oligomerize when activated and act as transcription factors
-
TGFβ receptor and disease
- TGFβ mediates fibrosis (too much TGFβ = fibrosis)
- TGFβ is anti proliferative and as such acts as a tumor suppressor; downstream SMADs are deleted in numerous cancers
-
SH2 domains
- Proteins with SH2 domains (conserved, non catalytic domain) are recruited to receptor tyrosine kinases
- Biological outcome is related to the combination of SH2 domain containing proteins recruited
-
Cytokine receptors
Receptor does not have kinase activity itself, but Jak kinase associated with receptor gets phosphorylated
-
Ras activation by receptor tyrosine kinase
- EGF binds receptor, receptor phosphorylates
- Recruits GRB2, which has SH2 domain (which is recruited by receptor) and SH3 domain (which associates with Sos), but no catalytic domain
- Now that Sos is recruited, Sos is activated, which then activates Ras, which activates Raf, which starts cascade to activate MAP kinase
|
|