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  1. Image Upload 2
    Xenopsylla cheopis primary vector of Bubonic plague
  2. Septicemic plague
    • ndotoxins cause disseminated intravascular coagulation
    • (DIC),
    • causing tiny clots,
    • ischaemic necrosis from the clots.
    • DIC results in depletes clotting resources and no longer control bleeding
  3. Plague vaccine is a vaccine used against
    Yersinia pestis
  4. Yersinia pestis (formerly Pasteurella pestis)
    • is a Gram-negative rod-shaped bacterium
    • Image Upload 4
  5. Tularemia gotten from?
    • via arthropod vectors leas ticks.
    • Resevoirs Rodents, rabbits, and hares
    • contact with contaminated animals or material
    • poorly cooked flesh of infected, water, or by inhalation
  6. Cause of Tularemia
    bacterium Francisella tularensis.[3] A Gram-negative, nonmotile coccobacillus,
  7. Francisella tularensis afeects what cells an dhow
    • live as a parasite within host cells.
    • It primarily infects macrophages,
  8. Image Upload 6
    R. rickettsii
  10. Spotted fever infects
    • the cells lining blood vessels
    • severe manifestations involve the respiratory system,
    • central nervous system, gastrointestinal system, or renal system.
  11. Vector of spotted_fever
    Image Upload 8
    • zoonotic diseases
    • ticks are the natural hosts, serving as both reservoirs and vectors of R. rickettsii.
  12. Typhus Fevers
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    caused by Rickettsiae
  13. Typhus in greak means
    smoky or hazy, describing the state of mind of those affected
  14. Treatment for typhus
    • doxycycline,tetracycline,chloramphenicol
    • Vaccine
  15. Q fever
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    • Coxiella burnetii obligate inracellular need just one
    • inhalation of particles in the air
    • milk, urine, feces, vaginal mucus, or semen of infected animals not tick borne
  16. Diagnosis of Q fever
    Diagnosis is usually based on serology[13][14] (looking for an antibody response) rather than looking for the organism itself
  17. Treatment of Q ferevr
    • Q-Vax inactivated vaccine
    • doxycycline, tetracycline, chloramphenicol, ciprofloxacin, ofloxacin, and hydroxychloroquine.
  18. syptoms of Q fever
    • incubates 2 to 3 weeks
    • flu like, fever, profuse sweat, head ache myalgia
    • can progress to pneumonia
    • chronic is like inflammation and can affect the heart
  19. About Coxiella burnetii
    • Q fever
    • gram negative
    • spore in soil
    • has been used as a bio weapon
  20. Lyme disease
    Borrelia burgdorferi
  21. Vector for
    Image Upload 14
    • lyme disease
    • deer tick
  22. Symptoms may of
    • include fever, headache, fatigue, depression, and a circular skin rash called erythema migrans
    • Left untreated, involve the joints, heart, and central nervous system.
  23. Borrelia burgdorferi
    Image Upload 16
    • Gram negative spirochete
    • can survive without iron
  24. vaccine for borrella dugdoferi
    • LYMErix but withdrawn
    • available for dogs
    • drugs: doxycycline (in adults), amoxicillin (in children), erythromycin (for pregnant women)
  25. post lyme disease
    arthritis, peripheral neuropathy and/or encephalomyelitis.
  26. Toxic shock syndrome
    • bacterial toxin
    • Staphylococcus aureus and Streptococcus pyogenes. Streptococcal TSS
  27. tss by staphylococcus aureus
    high fever, accompanied by low blood pressure, malaise and confusion, which can rapidly progress to stupor, coma, and multi-organ failure.characteristic rash, often seen early in the course of illness, resembles a sunburn
  28. TSS by Streptococcus Pyogenes
    • no rash
    • pre existing skin wound
    • becomes painful then frogress into similar staphylococcus aureus symtoms but no rash
  29. Special Note about TSS
    • Super Antigen bypass antigen presenting and initiate non specific activation of tcells and mass cytokine rlease
    • In patients with TSS, up to 20% of the body's T cells can be activated at one time. This polyclonal T-cell population causes a cytokine storm, followed by a multisystem disease.
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