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Xenopsylla cheopis primary vector of Bubonic plague
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Septicemic plague
- ndotoxins cause disseminated intravascular coagulation
- (DIC),
- causing tiny clots,
- ischaemic necrosis from the clots.
- DIC results in depletes clotting resources and no longer control bleeding
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Plague vaccine is a vaccine used against
Yersinia pestis
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Yersinia pestis (formerly Pasteurella pestis)
- is a Gram-negative rod-shaped bacterium
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Tularemia gotten from?
- via arthropod vectors leas ticks.
- Resevoirs Rodents, rabbits, and hares
- contact with contaminated animals or material
- poorly cooked flesh of infected, water, or by inhalation
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Cause of Tularemia
bacterium Francisella tularensis.[3] A Gram-negative, nonmotile coccobacillus,
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Francisella tularensis afeects what cells an dhow
- live as a parasite within host cells.
- It primarily infects macrophages,
-
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SPOTTED FEVER
R. rickettsii
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Spotted fever infects
- the cells lining blood vessels
- severe manifestations involve the respiratory system,
- central nervous system, gastrointestinal system, or renal system.
-
- zoonotic diseases
- ticks are the natural hosts, serving as both reservoirs and vectors of R. rickettsii.
-
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Typhus in greak means
smoky or hazy, describing the state of mind of those affected
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Treatment for typhus
- doxycycline,tetracycline,chloramphenicol
- Vaccine
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- Coxiella burnetii obligate inracellular need just one
- inhalation of particles in the air
- milk, urine, feces, vaginal mucus, or semen of infected animals not tick borne
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Diagnosis of Q fever
Diagnosis is usually based on serology[13][14] (looking for an antibody response) rather than looking for the organism itself
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Treatment of Q ferevr
- Q-Vax inactivated vaccine
- doxycycline, tetracycline, chloramphenicol, ciprofloxacin, ofloxacin, and hydroxychloroquine.
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syptoms of Q fever
- incubates 2 to 3 weeks
- flu like, fever, profuse sweat, head ache myalgia
- can progress to pneumonia
- chronic is like inflammation and can affect the heart
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About Coxiella burnetii
- Q fever
- gram negative
- spore in soil
- has been used as a bio weapon
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Lyme disease
Borrelia burgdorferi
-
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Symptoms may of
- include fever, headache, fatigue, depression, and a circular skin rash called erythema migrans
- Left untreated, involve the joints, heart, and central nervous system.
-
- Gram negative spirochete
- can survive without iron
-
vaccine for borrella dugdoferi
- LYMErix but withdrawn
- available for dogs
- drugs: doxycycline (in adults), amoxicillin (in children), erythromycin (for pregnant women)
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post lyme disease
arthritis, peripheral neuropathy and/or encephalomyelitis.
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Toxic shock syndrome
- bacterial toxin
- Staphylococcus aureus and Streptococcus pyogenes. Streptococcal TSS
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tss by staphylococcus aureus
high fever, accompanied by low blood pressure, malaise and confusion, which can rapidly progress to stupor, coma, and multi-organ failure.characteristic rash, often seen early in the course of illness, resembles a sunburn
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TSS by Streptococcus Pyogenes
- no rash
- pre existing skin wound
- becomes painful then frogress into similar staphylococcus aureus symtoms but no rash
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Special Note about TSS
- Super Antigen bypass antigen presenting and initiate non specific activation of tcells and mass cytokine rlease
- In patients with TSS, up to 20% of the body's T cells can be activated at one time. This polyclonal T-cell population causes a cytokine storm, followed by a multisystem disease.
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