-
first line for acute otitis media
- amoxicillin 80-90 mg/kg/day in 2 divided doses
- or
- augmentin 90 mg/kg/day in 2 divided doses
-
treatment of acute otitis media and a pcn allergy
cefdinir 14 mg/kg/day in 1 or 2 doses
-
3 common bug of community acquired pneumonia
- streptococcus pneumoniae
- haemophilus influenzae
- moraxella catarrhalis
-
empiric outpatient treatment of CAP
- macrolide (azithromycin, clarithromycin, erythromycin)
- or
- doxycycline
-
empiric inpatient (non-icu) treatment of CAP
-
empiric inpatient (ICU) treatment of CAP
- IV therapy preferred
- beta-lactam (ceftriaxone, cefotaxime, ampicillin/sulbactam)
- plus
- azithromycin or a FQ
-
oral antibiotic therapy for CAP
- cephalosporins
- cefpodoxime
- cefuroxime (ceftin)
- cefdinir
- macrolides
- azithromycin (zithromax)
- clarithromycin (biaxin)
- erythromycin
- FQ's
- levofloxacin (levaquin)
- moxifloxacin (avelox)
- gemifloxacin (factive)
- tetracyclines
- doxycycline (vibramycin)
- penicillins
- amoxicillin (amoxil)
- augmentin
-
regimen of choice for treating possible drug-resistant Strep. pneumoniae
beta-lactam + doxycycline
-
aminoglycoside renal dosing intervals
- CrCl > 60 = q8h
- 40-60 = q12h
- 20-40 = q24h
-
trough and peak levels of aminoglycosides
- tobramycin & gentamycin; P - 5-10, T <2
- amikacin; P - 20-30, T < 5
-
FQ MOA
inhibits topoisomerase, blocking DNA gyrase
-
pyrazinamide CI
- acute gout
- severe hepatic damage
-
treatment of choice for patients at risk of drug resistant S. pneumonia CAP
- respiratory fluoroquinolones
- at risk: age, co-morbidities
-
fluconazole PO:IV ration
1:1
-
metronidazole PO:IV ratio
1:1
-
-
typical drugs of choice for prophylactic peri-operative procedures
1st and 2nd gen cephalosporins
-
concentration dependent killing antibiotics
- aminoglycosides
- FQ's
- daptomycin
- colistin
-
time dependent killing antibiotics
beta-lactams
-
AUC:MIC dependent killing antibotics
- vancomycin
- macrolides
- tetracyclines
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