-
Beta blockers MOA
- inhibit B adrenergic receptors which decrease cardiac output
- DI: amidarone, venlafaxine, bronchodilators
- SE: bradycardia, bronchiospams, dizziness
- **dont use in pts with asthma and may block physiologic response to hypoglycemia
-
metoprolol
- Lopressor, toprol
- BB
- 25- 200mg
- DI: amidarone, venlafaxine, bronchodilators
- SE: bradycardia, bronchiospams, dizziness
- **dont use in pts with asthma and may block physiologic response to hypoglycemia
-
Propanolol
- inderal
- BB
- 80-480mg
- DI: amidarone, venlafaxine, bronchodilators
- SE: bradycardia, bronchiospams, dizziness
- **dont use in pts with asthma and may block physiologic response to hypoglycemia
-
atenolol
- tenormin
- BB
- 25-100mg per day
- DI: amidarone, venlafaxine, bronchodilators
- SE: bradycardia, bronchiospams, dizziness
- **dont use in pts with asthma and may block physiologic response to hypoglycemia
-
carvedolol
- coreg
- BB
- 12.5- 50 BID or 10-40 as ER
- DI: amidarone, venlafaxine, bronchodilators
- SE: bradycardia, bronchiospams, dizziness
- **dont use in pts with asthma and may block physiologic response to hypoglycemia
-
ARB MOA
- prevents angiotensin from binding to receptors
- DI: lithium, NSAID
- SE: renal insuffiency, hyperkalemia, orthostatic hypotension
- ***dont use with ACE***
-
Irbesartan
- Avapro
- ARB
- 150-300mg daily
- DI: lithium, NSAID
- SE: renal insuffiency, hyperkalemia, orthostatic hypotension
- ***dont use with ACE***
-
Valsartan
- Diovan
- ARB
- 80-320 daily
- DI: lithium, NSAID
- SE: renal insuffiency, hyperkalemia, orthostatic hypotension
- ***dont use with ACE***
-
Losartan
- Cozaar
- ARB
- 50-100mg daily
- DI: lithium, NSAID
- SE: renal insuffiency, hyperkalemia, orthostatic hypotension
- ***dont use with ACE***
-
Olmesartan
- Benicar
- ARB
- 20-40 daily
- DI: lithium, NSAID
- SE: renal insuffiency, hyperkalemia, orthostatic hypotension
- ***dont use with ACE***
-
ACE inhibitors MOA
- Inhibits Angiotension conversion from Angiotension I --II
- DI: KCL sparring diuretics, NSAIDS, Lithium
- SE: cough, renal insuffiency, hyperkalemia, angioemia
- ***dont use with ARB***
-
Lisinopril
- Zestril, Privinil
- ACE inhib
- 10-40mg daily
- DI: KCL sparring diuretics, NSAIDS, Lithium
- SE: cough, renal insuffiency, hyperkalemia, angioemia
- ***dont use with ARB***
-
ramipril
- altace
- ACE inhib
- 2.5-10 daily
- DI: KCL sparring diuretics, NSAIDS, Lithium
- SE: cough, renal insuffiency, hyperkalemia, angioemia
- ***dont use with ARB***
-
Enalapril
- Vastotec
- ACE inhib
- 5-40mg in 1-2 divided doses
- DI: KCL sparring diuretics, NSAIDS, Lithium
- SE: cough, renal insuffiency, hyperkalemia, angioemia
- ***dont use with ARB***
-
Benzepril
- Lotensin
- ACE inhib
- 10-40mg
- DI: KCL sparring diuretics, NSAIDS, Lithium
- SE: cough, renal insuffiency, hyperkalemia, angioemia
- ***dont use with ARB***
-
Quinapril
- Accupril
- ACE
- 10-80 daily
- DI: KCL sparring diuretics, NSAIDS, Lithium
- SE: cough, renal insuffiency, hyperkalemia, angioemia
- ***dont use with ARB***
-
Calcium Channel Blocker MOA
- block ca channels and cause relaxation of sm muscle which leads to vasodilation and dec in BP
- 2.5- 10mg
- DI: clipidogrel, fentanyl
- SE: bradycardia, edema, flushing, HA
- **dont use with heart failure**
-
Amlodipine
- Norvasc
- CCB- dihydropyrine-- works on peripheral vascualture
- 2.4-10mg
- DI: clipidogrel, fentanyl
- SE: bradycardia, edema, flushing, HA
- **dont use with heart failure**
-
Diltiazem
- Cardizam, tiazac
- CCB= non-dyhydropyrines- works on cardiac muscle
- 120-540mg
- DI: clipidogrel, fentanyl, statins
- SE: bradycardia, edema, flushing, HA
- **dont use with heart failure**
-
Nifedipine
- Procardia
- CCB- dihydropyridines-- work on peripheral vasculature
- 30-120mg
- DI: clipidogrel, fentanyl, statins
- SE: bradycardia, edema, flushing, HA
- **dont use with heart failure**
-
Verapimil
- Calan, Covera, Verelan
- CCB- non-dyhydropyridines -- work on cardiac muscle
- 100-480mg
- Di: digoxed, phenytoin, cyclosporin, lithium
- SE: bradycardia, edema, flushing, HA
-
Clonidine
- Catapress
- A2 agonists: stimulates a2 receptors in brain--> reducing sympathetic outflow to dec HR, CO and TPR
- oral: 0.1-0.8
- trans: 0.1-0.6
- DI: many, BB, and TCA
- SE: dizziness, drowsiness, xerostomia, constipation
-
Doxazosin
- Cardura
- a1 blocker, block the a1 receptor which results in smooth musle relaxaion: vasodilation
- 1-8 daily
- DI: PDE5 inhibitors
- SE: dizziness, drowsiness, sodium and fluit retentin, HA
-
HCTZ
- hydrouril
- thiazide: inc amt of sodium and cl exreted in distal tubule of kidney
- 12.5-100mg per day
- DI: digoxen, corticosteroids, NSAIDs
- SE: photosensitivity, sexual dysfunction
- **may cause sulfa allergy***
-
Furosemide
- Lasix
- loop diruetic: blocks absorption of Na and CL in the loop of henle
- 20-80 daily
- DI: corticosteroids, aminoglycosides, NSAID
- SE: hypuricemia, hypokalemia
- ***may react with sulfa***
-
Spironolactone
- Aldactone
- Aldoserone antagonist: k sparring- competes with aldosterone at NA K exchange site of distal to inc k retention and increase na excretion
- 25-200
- DI: ACE, NSAID, triamterine, potassium
- SE: hyperkalemia, gynecomastia, HA, NVD
-
Triamterine/HCTZ
- Diazide, Maxide
- Potassium sparring + thiazide
- 37.5-75, 25-50mg
- DI: ace, NSAID, triamterine, potassium, digoxen, corticosteroids, hypokalemia, NSAID,
- SE: hyperkalemia, gynecomastia, HA, NVD, photosenstivity, sexual dysfunction, cross react with sulfa
-
Lisinopril/HCTZ
- Zestoretic
- ACE + thiazide
- 10-20/ 12.5
-
Valsartan/HCTZ
- Diovan HCT
- ARB + thiazide
- 80-160/ 12.5-25
-
losartan/ hctz
- hyzaar
- arb + thiazide
- 50-100/ 12.5-25mg
-
olmetartan/hctz
- Benicar HCT
- 20-40/ 12.5-25
-
Amlodipine/Benzepril
- Lotrel
- CCB + ACE
- 2.5-10/ 10-40
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