Ch 4 2 Pharm

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Inverse agonists
- Drug binds to same receptor as the agonist but has the opposite effect of the agonist on cellular function
- Decreases over stimulated activity
Desensitization

Overstimulation of receptor leading to change in receptor decreasing binding
Down-regulation

Decrease in receptor numbers due to prolonged exposure of agonist
Supersensitivity
- decrease in stimulation of receptors leading to increase in receptor sensitivity
- Ex: severed peripheral nerve
- Ex: loss of endogenous NT dopamine in Parkinson Disease
Up-regulation

Increase in receptor numbers due to decreased exposure of agonist
Non-receptor actions
- exerting effect through mechanisms that don’t involve binding to a specific cellular component
- used in biosynthesis
- bind to harmful metals to prevent them exerting their effects

Author

303859

Card Set

Ch 4 2 Pharm

Description

Ch 4 2 Pharm

Updated

2015-06-09T18:54:49Z

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