DL - Final 3

  1. Does Lexapro or Celexa have a faster OOA?
    Lexapro by 1-2 weeks
  2. Is Lexapro or Celexa superior?
    Lexapro has not been shown to be superior to Celexa or to have less side effects than Celexa.
  3. How is Celexa metabolized?
    Hepatic metabolism is primary
  4. T1/2 of Celexa is increased by 50% in ___________.
    The elderly
  5. The oral clearance of _________________ is decreased 37% in liver impairment and t1/2 is increased 50%.
  6. The oral clearance of Celexa is decreased 37% in _____________________ and t1/2 is increased__________.
    • liver impairment
    • 50%
  7. First approved SSRI in the US and the longest half life of all the SSRI’s is:
  8. What is Prozac indicated for?
    • Depression, OCD, bulimia nervosa, panic disorder, PTSD
    • Geriatric depression
    • Pediatric use in depression and OCD
    • Sarafem – PMDD
  9. Prozac weekly is used for what?
    Maintenance treatment of depression
  10. How/When should patients take Prozac?
    • Morning or night based on how it effects them
    • > 40 mg-divide in two doses- morning and afternoon
    • Weekly-swallow whole, don’t crush, chew, or cut
  11. How does Prozac compare to other SSRIs?
    Slower onset of action
  12. What are the pharmacokinetic parameters of Prozac?
    • Potent Inhibitor of CYP 2D6
    • Inhibits CYP 3A4
    • Food can delay rate of absorption, but not bioavailability
    • Elderly metabolize similarly to younger people
    • Hepatic impairment can delay elimination
  13. What are the dosage forms available for Paxil?
    • CR = 12.5, 25, 37.5 mg
    • IR = 10, 20, 30, or 40mg and 10mg/5ml suspension
  14. How many active metabolites does Paxil have?
    No active metabolites
  15. What SSRI has the highest affinity for serotonin receptors?
  16. What are the indications for Paxil?
    Adults with depression, depression complicated by anxiety, and for all the major anxiety syndromes, OCD, panic disorders, social anxiety
  17. Paxil has what DDIs?
    Potent inhibitor of CYP 2D6
  18. Should you take Paxil with food?
    Bioavailability is not affected by food
  19. What groups need lower doses of Paxil?
    Elderly, renal, and liver impaired
  20. When there are questionable drug interactions ______________________ should be first choice because they have lower risks of drug interactions.
    Citalopram or Sertraline
  21. In a patient who is prone to SSRI adverse effects do not give __________________ due to increased GI side effects.
    Paroxetine - Paxil
  22. ____________________ is a good choice for patients who are poorly compliant or who have had trouble with discontinuation of antidepressants previously.
    Fluoxetine – Prozac
  23. What are the dosage forms available for Cymbalta?
    20, 30 and 60 mg
  24. _______________________ is effective in treating depression and improves the painful physical symptoms of depression. It can also be used to treat Generalized Anxiety Disorder.
  25. Those with preexisting liver disease may have increasing liver damage with ____________________.

    • When should Cymbalta be avoided?
    • Substantial alcohol use and or chronic liver disease
    • Don’t give with any liver impairment
  26. How do you administer Extended-release Effexor capsules:
    • As a single dose
    • With food to decrease GI upset
    • Morning or evening
    • At the same time each day
    • Swallow whole with plenty of fluids
    • Alternatively - open capsule and sprinkling the entire contents on a spoonful of applesauce, swallow immediately without chewing and follow w/ a glass of water
  27. What are the major SE of Effexor?
    HTN or a faster heart rate
  28. What are TCAs usually used for?
  29. What are the common SE of TCAs?
    • Dry mouth (use gum)
    • Dry eyes
    • Blurred vision (used lubricating drops)
    • Sun sensitivity
    • Sedation
Card Set
DL - Final 3
DL - Final