Immunology Comprehensive Study

Protein Phosphatases
- enzymes that remove phosphate groups from proteins
- regulate signaling by "resetting" proteins to original state switching signal "off"
Protein Kinase Roles
- 1. receptor activation
- 2. activate cell response machinery
- 3. regulate activty of enzymes by signaling phosphorylation/dephosphorylation
Protein Kinases

catalyze covalent attachment of phosphate group to a protein by protein phosphorylation
Protein Kinase receptor types
- 1. enzymatic activity via kinase intricate part of receptor
- 2. non-enzymatic via kinase non-covalently bonded to receptor
Phosphorylation associated with receptor activation occurs on which three amino acids
- Tyrosine (tyrosine kinases)
- Serine/threonine (serine/threonine kinases)
Intracellular Signalling Pathway

proteins that interact to transmit signal inside cell
Signal transduction

process that convert external signal to biochemical forms
ITAM
- Immunoreceptor Trosine-based Activation Motif
- Needed by both BCR and TCR in order to be displayed on cell surface and to perform signaling functions
lymphocyte antigen receptors are what type of receptors

tyrosine-associated receptors

Author

hlwillson

30209

Card Set

Immunology Comprehensive Study

Description

Comprehensive Exam study

Updated

2010-08-18T20:46:00Z

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