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What are the EGFR inhibitors?
- Cetuximab
- Panitumumab
- Gefitinib
- Erlotinib
- Afatinib
- Sorafenib, TKI & Vandetinib (mixed action)
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What are the HER2/Neu inhibitors?
- Trastuzumab
- Pertuzumab
- Lapatinib
- TKI (mixed)
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What are the Bcr-abl inhibitors?
- Dasatinib
- Bosutinib
- Ponatinib
- Nitotinib
- Imatinib
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What are the ALK inhibitors?
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What are the Angiogenesis inhibitors?
- Bevacizumab
- Ramucirumab
- Axitinib, Sorafenib, Regorafenib, Ziv-Aflibercept, Vandetanib, Lenvatinib & Pazopanib (mixed)
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What are the Proteasome inhibitors?
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What is the generic name for Avastin:
Bevacizumab
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What is the generic name for Erbitux:
Cetuximab
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What is the generic name for Rituxan:
Rituximab
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What is the generic name for Gleevec:
Imatinib
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What is the generic name for Herceptin:
Traztuzumab
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What is the generic name for Yervoy:
Ipilimumab
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What is the generic name for Tykerb:
Lapatinib
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What is the generic name for Tarceva:
Erlotinib
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What is the brand name for bevacizumab?
Avastin
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What is the brand name for cetuximab?
Erbitux
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What is the brand name for rituximab?
Rituxan
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What is the brand name for imatinib?
Gleevec
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What is the brand name for traztuzumab?
Herceptin
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What is the brand name for ipilimumab?
Yervoy
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What is the brand name for lapatinib?
Tykerb
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What is the brand name for erlotinib?
Tarceva
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What are the CD20 MABs?
- Rituxumab
- Ibritumomab tiuxetan
- Ofatumumab
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What are the CTLA-4 mabs?
Ipilimumab
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What does o before –mab mean?
Mouse
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What does xi before –mab mean?
Chimeric
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What does zu before –mab mean?
Humanized
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What does u before –mab mean?
Human
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What type of cells are targeted by Rituimab and what type of killing (indirect or direct) is employed?
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What are the toxicities of Rituximab?
- Tumor lysis
- Reactivation of Hep B, CMV, etc.
- Infusion reactions – slow infusion to prevent, 1st time is worst
- Anaphylaxis – pretreat w/ APAP and diphenhydramine
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What type of cells are targeted by Ofatumumab and what type of killing (indirect or direct) is employed?
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What are the toxicities of Ofatumumab?
- Infusion reactions
- Prolonged thrombocytopenia and neutropenia
- Reactivation of Hep B
- GI obstruction
- Severe infections
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What drugs cause reactivation of HepB?
Rituxumab, Obinutuzumab, Ofatumumab
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What type of cells are targeted by Obinutuzumab and what type of killing (indirect or direct) is employed?
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What are the toxicities of Obinutuzumab?
- PML
- Reactivation of Hep B
- Prolonged neutropenia
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What mabs cause prolonged neutropenia?
- Obinutuzumab and Ofatumumab
- Alemtuzumab
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How do you prevent infusion reactions with Ofatumumab and Obiutuzumab?
- Ofatumumab: APAP 100 mg + antihistamine + steroid
- Obiutuzumab: 1st cycle, APAP 650 mg + Antihistamine + steroid, later cycles just APAP 650 – hold HTN drugs 12 hours prior
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What is the indication for Alemtuzumab?
B cell CLL
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