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Therapeutics - Prostate Cancer 1

  1. What drugs can falsely lower PSA levels by 50% with 6-12 months of use?
    • Finasteride, dutasteride
    • Androgen receptor blockers (bicalutamide, flutamide)
    • Some herbs (Saw Palmetto)
  2. What are the American Cancer Society’s guidelines for Prostate cancer screening?
    • Discussed and Offered:
    • Life expectance is > or = to 10 years
    • After age 50
    • Age 45 for African Americans or strong family history
  3. When is treatment started for prostate cancer?
    When a ptient with LE of > or = 10 years shows tumor progession
  4. When is palliative care started for prostate cancer?
    When a patient with < 10 years LE shows tumor has started to progress
  5. The first choice treatment for Prostate cancer is:
    • Prostatectomy
    • Followed by Radiation +/- ADT therapy
  6. How long is Radiation and ADT therapy continued in a high risk patient with prostate cancer?
    2-3 years
  7. How long is Radiation and ADT therapy continued in a low risk patient with prostate cancer?
    3-6 months
  8. How can you reduce side effects of Andorgne deprivation therapy?
    Intermittent therapy
  9. When should you do continuous androgen deprivation therapy in prostate cancer?
    When the gleason score is > or = to 8
  10. What drug classes are used for androgen deprivation therapy?
    • LH-RH AGONISTS
    • Antiandrogens
  11. What are the LH-RH agonists:
    • Goserelin (Zoladex)
    • Leuprolide (Lupron)
    • Triptorelin (Trelstar LA)
  12. What drug class does Goserelin (Zoladex) fall into?
    LH-RH AGONISTS
  13. What drug class does Leuprolide (Lupron) fall into?
    LH-RH AGONISTS
  14. What drug class does Triptorelin (Trelstar LA) fall into?
    LH-RH AGONISTS
  15. What drug class does Degarelix (Firmagon) fall into?
    LH-RH Antagonists
  16. What drug class does Abaralix (Plenaxis) fall into?
    LH-RH Antagonists
  17. What are the SE of LH-RH agonists?
    • Hot flashes
    • Injections site reactions
    • Sexual dysfunction
    • HA
    • OP – give Ca and Vit D
    • Increased risk of DM or CV
    • MI
    • Weight gain
    • Tumor flare with metastatic disease– control with antiandrogens
  18. What drugs can be sued to control tumor flare?
    Antiandrogens
  19. All men over 50 receiving LH-RH agonists or ANTagonists should receive what other drugs and why?
    • For prevention of fractures form OP:
    • Calcium 1200 mg QD
    • Vitamin D3 800-1000 IU QD
    • FRAX assessment
    • Bisphosphonates may be used – Zolendronic HA or Alendronate
  20. What are the Antiandrogens?
    • Bicalutamide (Casodex)
    • Flutamine (Eulexin)
    • Nilutamide (Nilandrone)
  21. What are the treatment options for Castrate sensitive metastatic disease?
    • ADT therapy
    • Or
    • Bilateral orichietomy
    • Or
    • LH-RH agonist/antagonists +/- antiandrogens
  22. What are the LH-RH ANTagonists?
    Degarelix (Firmagon)
  23. What is the brand name for Goserelin?
    Zoladex
  24. What is the brand name for Leuprolide?
    Lupron
  25. What is the brand name for Triptorelin?
    Trelstar LA
  26. What is the brand name for Degarelix?
    Firmagon
  27. What is the generic name for Zoladex?
    Goserelin
  28. What is the generic name for Lupron?
    Leuprolide
  29. What is the generic name for Trelstar LA?
    Triptorelin
  30. What is the generic name for Firmagon?
    Degarelix
Author
kyleannkelsey
ID
301920
Card Set
Therapeutics - Prostate Cancer 1
Description
Therapeutics - Prostate Cancer
Updated

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