ABSITE chapter 7 medicines and pharmacology.txt

Drug administration routes that do not require passage through the liver first

Drug absorption limited to nonionized, lipid soluble drugs

Molecule largely responsible for binding drugs

Drug pharmacokinetics where a constant amount is eliminated regardless of dose

drug pharmacokinetics where drug elimination is proportional to dose

number of half lives to reach a steady state

amount of drug in body/amount of drug in plasma

fraction of unchanged drug reaching the systemic circulation

drug level at which desired effect occurs in 50% of patients

Drug level at which death occurs in 50% of patients

Tolerance gained after only a few doses

Dose required for drug to take effect

Ability of a drug to achieve results without untoward effects

Inhibitors of P-450 (11)

Inducers of P-450 (7)

Most important organ for eliminating drugs

Water soluble drugs, more likely to be eliminated unaltered

Fat soluble drugs, more likely to be metabolized before excretion

Anti-inflammatory that binds tubulin and inhibits migration

Anti-inflammatory used in gout

Xanthine oxidase inhibitor that blocks uric acid formation from xanthene, used in uric acid chronic overproducers

Gout drug that increases renal secretion of uric acid; used for undersecreters

Dopamine receptor blocker that can be used to increase gastric motility

Serotonin receptor inhibitor used as an antiemetic

Long-acting somatostatin analog

Drug that inhibits Na/K ATPase and increases myocardial calcium, increasing atrial contraction but slowing AV conduction

Drug used to treat torsades

Drug that causes transient disruption of the AV node

Best single agent shown to reduce mortality in CHF patients

Drugs that reduce risk of MI and Afib postoperatively

Acetylcholine antagonist that increases heart rate

2 drugs that inhibit adrenal steroid synthesis

GnRH analog that inhibits LH and FSH release from pituitary

Drug that acts on V1 receptors as a contrictor; can be used in GI bleeding by reducing blood flow

Prostaglandin inhibitor used to close PDA in children; also used in gout

PGE1 derivative used to prevent PUD

Prostaglandin synthesis inhibitors, lead to dec mucus and HCO3- secretion and inc acid production

Symptoms of ASA poisoning (5)

Treatment of Tylenol overdose

Fibrinolytic used in sepsis; inactivates the inhibitor of protein C