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The capacity for repair and resolution is _________-dependent based on __________ and the ___________ of various cell populations.
tissue; vascularity; post-differentiation replicative ability
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Cell numbers fall during resolution due to.. (3)
decreasing gradients of chemotactic factors, necrosis, and apoptosis
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What are the 4 stages of healing?
hemostasis (immediate) --> acute inflammation removes irritant --> proliferation forms granulation tissue --> remodeling causes wound contraction and re-epithelialization
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Process whereby damaged cells are replaced by cells of the same phenotype, yielding complete restoration.
regeneration repair
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3 types of labile cells (continuously replicating throughout life).
BM, mucosal and cutaneous tissues
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3 types of stable cells (have some post-natal proliferative potential).
parenchyma in kidney, liver, and glandular endocrine organs
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3 types of permanent cells (have no postnatal mitotic potential).
cardiac and skeletal muscle, neurons
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Process whereby damaged tissue that cannot be otherwise repaired is replaced with fibrous connective tissue, resulting in a cicatrix (scar).
substitution repair
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Principals for promotion of proper healing and repair. (4)
minimize damage, contain tissue drying, promote repair by tissue debridement and a good supportive environment
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In non-mammals, the predominant acute inflammatory cell type is _________.
heterophils
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In non-mammals, simple bacteria induce _____________.
heterophilic granulomas
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In non-mammals, complex bacteria induce ______________.
pure granulomatous inflammation
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In non-mammals, re-epithelialization grows ___________; in mammals, re-epithelialization grows ____________.
over the clot; from underneath the surface as exudate
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In non-mammals, fibroplasia and neovascularization develop from ______________; in mammals, it develops from _____________.
from the base of the wound vertically; from the sides
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In non-mammals, wound healing is a ______________ process.
temperature-dependent
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