-
What are the Common uses for Teniposide?
NHL, SCLC, bladder
-
What are the SE for Teniposide?
Hypotension – rate dependent
-
What special information should you know about Teniposide?
No PVC-containing products
-
What drug can be used as an antidote to extravasation by anthracyclines?
Totect
-
What are the class effects fo anthracycline derivatives?
- Radiation recall
- Vesicants (treat with Totect)
- Red Urine
- Delayed Cardiotoxicity (DLT, HT)
-
What are the Anthracyclines?
-rubicin
-
What are the Common uses for Doxorubicin?
Breast, NHL, bladder, sarcoma, MM
-
What are the SE for Doxorubicin?
Cardiotoxicity (DLT, HT) – delayed (acute is not really an issues, as it is usually self-resolving)
-
What special information should you know about Doxorubicin?
- Baseline ejection fraction before treatment – cannot be low, must be > 40
- Max dose of 550 mg/m2
-
What are the Common uses for Daunorubicin?
AML and ALL
-
What are the SE for Daunorubicin?
Cardiotoxicity (DLT, HT) – delayed (acute is not really an issues, as it is usually self-resolving)
-
What special information should you know about Daunorubicin?
- Baseline ejection fraction before treatment – cannot be low, must be > 40
- Max dose of 550 mg/m2
-
What are the Common uses for Idarubicin?
AML and ALL
-
What are the SE for Idarubicin?
Cardiotoxicity (DLT, HT) – delayed (acute is not really an issues, as it is usually self-resolving)
-
What special information should you know about Idarubicin?
- Baseline ejection fraction before treatment – cannot be low, must be > 40
- Max dose of 150 mg/m2
-
What are the Common uses for Epirubicin?
Breast, SCLC, NSCLC, NHL, bladder, ovarian
-
What are the SE for Epirubicin?
Cardiotoxicity (DLT, HT) – delayed (acute is not really an issues, as it is usually self-resolving)
-
What special information should you know about Epirubicin?
- Baseline ejection fraction before treatment – cannot be low, must be > 40
- Max dose of 900 mg/m2
-
What are the Common uses for Mitoxantrone?
Prostate cancer, MM
-
What are the SE for Mitoxantrone?
Cardiotoxicity (DLT, HT), blue green discoloration of urine, skin, sclera
-
What are the SE for Busulfan?
- Pulmonary fibrosis “Busulfan lung” (Short survival after diagnosis)
- Usually occurs after 3-4 years of treatment
- Presentation: Non-productive cough, Shortness of breath, weight loss, Abnormal chest x-ray
-
What special information should you know about Mitoxantrone?
- Baseline ejection fraction before treatment
- Do not exceed 140 mg/m2
-
What special information should you know about Busulfan?
- Readily crosses blood brain barrier
- CNS levels = plasma levels
- Stem cell transplant/bone marrow transplant
- Seizures –Prophylax with phenytoin (Keppra also used) for 48-72 hrs after dose completed
- IV and PO = not interchangeable
|
|
