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What are the Common uses for 5FU?
- Colorectal
- Breast
- H &N
- Pancreatic
- Gastric
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What are the SE for 5FU?
- Stomatitis (HT, DLT)
- Diarrhea (HT, DLT)
- H & F syndrome
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What special information should you know about 5FU?
- Radiosensitizer
- Leucovorin enhances activity and toxicity
- DDI with Warfarin
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What are the Common uses for Capecetibine?
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What are the SE for Capecetibine?
- Diarrhea
- Stomatitis
- H & F syndrome (HT, DLT)
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What special information should you know about Capecetibine?
- Prodrug of 5FU
- Oral tablet
- Hand and Foot Syndrome = desquamation, pain, bleeding, ulceration
- DDI w/ warfarin
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What are the Common uses for Cytarbine?
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What are the SE for Cytarbine?
- Std dose: Myelosupression
- >1gm/m2: Cerebellar syndrome (DL, HT), conjunctivitis
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What special information should you know about Cytarbine?
Neuro checks before each dose for Cerebellar syndrome (slurred speech, ataxia, confusion)
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What are the Common uses for Azacitidine?
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What are the SE for Azacitidine?
- Myelosupression
- Febrile neutropenia
- Fever
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What special information should you know about Azacitidine?
- No live vaccines
- <5% cardiac problems (A fib and CHF)
- SQ injection
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What are the Common uses for Decitabine?
CDL, MDS and AML
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What are the SE for Decitabine?
- Hyperglycemia (HT)
- Edema
- Pneumonia
- Decreased K and Mg
- Myelosupression
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What special information should you know about Decitabine?
- No live vaccines
- <5% cardiac toxicity (A fib or CHF)
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What are the Common uses for Gemcitabine?
- NSCLC and Metastatic Breast cancer
- Increased QOL – DOC – Pancreatic cancer
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What are the Common uses for Methotrexate?
All, NHL, breast cancer, Osteosarcoma
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What are the SE for Methotrexate?
- LD: Hepatotoxicity and pulmonary toxicity
- HD: Myelosupression, Mucositis and Diarrhea (HT and DL), Nephrotoxicity (HT)
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What special information should you know about Methotrexate?
- DDI with Bactrim and NSAIDs
- Hyrdrate w/ Bicarb, keep urine >7 pH until drug levels are safe
- Rescue: give leucovorin 24-36hr post dose with doses >100 mg/m2, use until levels drop below 0.05 or 0.02
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What are the Common uses for Pemetrexed?
NHL and Peripheral T-cell lymphoma
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What are the SE for Pemetrexed?
Myelosupresssion, Edema, Mucositis and Diarrhea
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What special information should you know about Pemetrexed?
- DDI with Bactrim and NSAIDs
- Rescue: Folic Acid 1 mg/day (10 days before and 30 days after)
- B12 100 mcg IM before and Q9wk
- Dexamethasone 4 mg BID x3 days, starting before therapy
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What are the Anti-microtubule agents?
- Taxanes: -taxel
- Vinca Alkaloids: Vin-ine
- Estramustine
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What are the Common uses for Paclitaxol?
- Breast
- Ovarian
- Gastric
- NSCLC/SCLC
- H & N
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What are the SE for Paclitaxel?
- Peripheral neuropathy (DLT)
- Complete alopecia (HT)
- Hypersensitivity
- Myalgias
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What special information should you know about Paclitaxel?
- Premedicate with Dexa, Benadryl and H2 antagonist
- NO PVC
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What are the Common uses for Paclitaxel NAB?
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What are the SE for Paclitaxel NAB?
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What special information should you know about Paclitaxel NAB?
- Not dose equivalent to Paclitaxel
- No pre-meds
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What are the Common uses for Docetaxel?
- Breast
- NSCLC
- H & N
- Prostate
- Gastric
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What are the SE for Docetaxel?
- Edema (HT)
- PN
- Complete alopecia
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What special information should you know about Docetaxel?
- Dexamethasone 8 mg BID x 3 days
- NO PVC
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What are the Common uses for Cabazitaxel?
Hormone refractory metastatic prostate cancer
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What are the SE for Cabazitaxel?
- Neutropenia
- N/V
- Diarrhea
- Hypersensitivity
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What special information should you know about Cabazitaxel?
- CYP3A4 metabolized
- No PVC
- Pre-medicate with Dexa, Benadryl and H2 antagonist
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What are the Common uses for Ixabepilone?
Breast and Prostate cancer
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What are the SE for Ixabepilone?
- PN (DLT)
- Hypersensitivity
- Myalgias
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What special information should you know about Ixabepilone?
- CYP3A4 metabolized
- No PVC
- May cause cardiac dysfunction
- Pre-medicate with Benadryl and H2 antagonist (Dexa if hypersensitivity occurs)
- CI in hepatotoxicity
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