-
Atorvastatin
- lipitor
- hmgcoa reductase inhibitor
- 10-80mg 1 x day
- fibrates and niacin --> inc myopathy
- warfarin, macrolides
- 3a4 inhib
- dyspepsia, diarrhea, mypoathy, rhabdomyloys
-
simvastatin
- zocor
- hmgcoa reductase inhib
- 5-80mg po 1 x day
- fibrates and niacin --> inc myopathy
- warfarin, macrolides
- 3a4 inhib
- dyspepsia, diarrhea, mypoathy, rhabdomyloys
-
lovastatin
- mevacor
- hmgcoa reductase inhib
- 10-80mg in 1-2 divided doses
- fibrates and niacin --> inc myopathy
- warfarin, macrolides
- 3a4 inhib
- dyspepsia, diarrhea, mypoathy, rhabdomyloys
-
rosuvastatin
- crestor
- hmg coa reductase inhib
- 5-40mg 1 x day
- fibrates and niacin --> inc myopathy
- warfarin, macrolides
- dyspepsia, diarrhea, mypoathy, rhabdomyloys, elevated liver enzymes
-
pravastatin
- pravachol
- hmgcoa reductase inhib
- 10-80 mg 1 x day
- fibrates and niacin --> inc myopathy
- warfarin, macrolides
- dyspepsia, diarrhea, mypoathy, rhabdomyloys, elevated liver enzymes
-
ezetimbime
- zetia
- cholesterol absroption inhibitor
- 10mg 1 x day
- bile acid resins, cyclosporins, fibrates
- GI upset, diarrhea, fatigue
-
ezetimibe/simvastain
- vytorin
- stain + cholesterol absorption inhibiton
- 10/10 - 10/80
- bile acid resins, cyclosprin, fibrates, niacin, warfarin, macrolides, 3a4 inhib
- GI upset, diarrea, fatigue, dyspepsia, mypopathy, rhabdomyloys, elevated liver enzymes
-
fenofibrate
- tricor
- fibrate: activation of peroxisome PPAR that activate lipase and dec apoC III leading to clearance of TG
- 48-145 mg po daily
- statins, niacin, warfarin, rosiglitazone, glyburide,
- dyspepsia, myopathy, gallstones, elevated liver enzymes
-
gemfibrozil
- lopid
- fibrate: activation of PPAR that activate lipase and dec apo c II leading to clearance of tg
- 600mg po bid
- statins, niacin, warfarin, rosiglitazone, glyburide,
- dyspepsia, myopathy, gallstones, elevated liver enzymes
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