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solid dosage form usually prepare with the aid of a suitable pharmaceutical excipients
tablets
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3 basic methods of tablets
- wet granulation
- dry granulation
- direct compression
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widely employed method for production of compressed tablet
wet granulation
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7 steps in wet granulation
- weighing and blending ingredients
- prepare the dampened mass
- screening mass into pellets or granules
- drying the granulation
- dry screening
- lubrication
- compression
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equipments that prepare the granules
extrusion
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continuous fluid bed process is the process of granulation used, using a single piece of equipemnt, the fluid bed granulator
all in one granulation
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molder in making molded tablet is made up of
hard rubber, hard plastic and metal
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2 parts of molder
- upper - die portion
- lower - flat punches
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pleasant tasting tablets formulated to designate smoothly in the mouth
chewable tablets
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is a white crystalline hexahydric alcohol that is 70% as sweet as sucrose
mannitol
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uses of coated tablet
- for protection
- mask taste
- special characteristic
- distinction from other products
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process in making sugar coated tablets
- waterproofing or sealing
- subcoating
- smoothing and final
- finishing and coloring
- polishing
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differentiate debossed, embossed and engraved
debossed - imprinted with a mark below the surface
embossed - imprinted with a mark above the surface
engraved - imprinted wit a code that is cut into the surface
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places a thin, skintight coating of a plastic like material over the compressed tablet
film coating process
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types of film coating
- immediate release
- modified release
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3 reasons of film coating
- protect stomach from drug
- protect drug from stomach
- release drug after the stomach
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in what pH does the enteric coated tablet be dissolved in the intestinw
pH 4.8
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materials used in enteric coating
- shellac
- hydroxypropyl methylcellulose phthalate
- polyvinyl acetate phthalate
- diethyl phthtale
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is spray coating of powders, granules, bead, pellets or tablets held in suspension by a column of air
fluid bed coating
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other name of bottom spray method
wurster process
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technique used for layering coatings and for sustained release and enteric coated products
tangential spray technique
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agents used to increase spreadability
surfactants
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agents used for flexibility and elasticity
plasticizer
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