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Anixety meds
- Benzodiazephine sedative hypnotic anxiolytics (Valium)
- Atypical anxiolytic/nonbarbiturate anxiolytics (BuSpar)
- Antidepressents such as Paxil, Zoloft and Effexor, Elavil, Anafranil
- Antihistamines (Vistaril) and (Atarax)
- Beta blockers (Inderal)
- Anticonvulsants (gabapentin)
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Benzo action
enhances the inhibitory effects of GABA in the central nervous system, relief from anxiety occurs rapidly
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Benzo use
- seizure
- insominia
- muscle spasm
- alcohol withdrawl
- induction of anesthesia
- amnesic
- short term use
-
Benzo side effects
- sedation, light headedness, ataxia, decreased cognitive function
- Anterograde amnesia- difficulty recalling events that occur after dose
- Acute toxicity (oral- drowsiness, lethargy, confusion, IV- resp depression, severe hypotension, cardiac arrest)
- Paradoxical effects
- withdrawal effects
-
Benzo contraindications
- schedual 4
- preganacy D
- sleep apena
- resp depression
- glaucoma
- liver disease
- DONT CHEW
- TAKE WITH FOOD
-
Atypical anxiolytics action
- binds to seratonin and dopamine receptors. Less dependency and sedation
- Used with MAOI antidepressents
- 3-6 weeks to work
-
Atypical anxiolytic uses
- Panic disorder
- OCD
- social anxiety disorder
- PTSD
-
Atypical anxiolytic complications
- dizziness, nausea, headache, agitation
- Dont take with St. Jons wort, grapefrutit juice
-
SSRI purpose for anxiety
- inhibits seratonin reuptake, allowing more to stay at the junction of the neurons
- 4 weeks to work
- causes insomnia
- used for GAD, panic disorder, OCD, social anxiety, trauma and stressor, depression
-
SSRI complications
- nausea, diaphoresis, tremor, fatigure, drowsiness
- sexual dysfunction, weight gain 20 lbs or more
- GI bleeding
- hyponatremia
- Serotonin syndrome
- Bruxism
- Use cautiously in bipolar due to risk for mania
-
Take SSRI in morning to reduce
sleep disturbances
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Antidepressants
- Tricyclic antidepressents
- SSRI
- MAOI
- Atypical antidepressents
-
Trycilic purpose
- block reuptake of norepi and serotonin in the synaptic space
- used for depressive disorders
-
Adverse effects of Tryclic
- anticholinergic effects
- orthostatic hypotension
- sedation
- toxisity
- decreased seizure threshold
- excessive sweating
-
Do not take Tryclic with
- MAOI
- Antihystamines
- alcohol, benzo, opiods,
-
MAOI purpose
- block MAO in the brain, increasing amount of norepi, dopamine, serotonin
- USed for depression and bulimia
-
Adverse of MAOI
- CNS stimulation(anxiety, agitation, hypomania, mania)
- orthostatic hypo
- hypoertensive crisis if taken with tyramine
- local rash associated with transdermal preparation
-
Atypical antidepressant purpose
- inhibits dopamine uptake
- used to treat depression, sexual dysfunction, quit smoking, seasonal pattern depression
-
Atypical antidepressant adverse
- headache, dry mouth
- GI
- constipation
- increased hr
- nausea
- restlessness
- insomnia
- weight loss
- seizures
-
Do not take atypical antidepressants if you have
-
Bipolar meds
- lithium
- depakote
- tegretol
- lamictal
- antidepressions
- anxiolytics
- atypical antiphsychotics
-
Lithium purpose
serotonin receptor blockade
-
Lithium adverse
- GI
- fine hand tremors
- polyuria
- thirst
- weight gain
- renal tox
- goiter
- hypotension
-
lithium takes affect in
7-14 days
-
Depakote purpose
- slowing entrance of sodium and calcium into neuron
- Used for manic and depressive episodes, rapid cycling and mixed mania
-
Carbamezapine adverse
- CNS effects
- Nystagmus
- double vision
- vertigo
- staggering gait
- headache
- blood dyscrasias
- teratogenesis
- hypoosmolarity
- skin disorders (Stevens Johnson syndrome)
-
Lamotrigine adverse
- doubel vision, n/v, dizziness
- serious skin rashes (stevens johnson syndrome)
-
Depakote advrse
- GI
- Hepatotox
- Pancreatitis
- Thrombocytopenia
- Teratogenesis
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