-
Strategy for inducing immunoprotection that results in rapid but temporary protection; eg. colostral Ab.
passive
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Strategy for inducing immunoprotection that takes longer but provides longer lasting immunity; eg. vaccination.
Active
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Vaccines that require fewer and smaller doses and induce longer lasting immunity.
Live vaccines
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Live vaccines induce ______ and stimulate...
IFN; humoral and cell-mediated immunity.
-
Vaccines that are more stable and storable and are unlikely to cause disease.
Non-live vaccines
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4 types of non-live vaccines.
inactivated virus, purified subunits, recombinant products, and DNA vaccine
-
Modified live vaccines are _________.
attenuated
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Inactivated vaccines have the ______________.
whole organism killed or fixed
-
Recombinant vaccines either...
purify out a component (purified sub-unit) or utilize a vector to produce a sub-unit (recombinant)
-
3 types of antibacterial vaccines.
toxoids, bacterins, modified live
-
Toxoid antibacterial vaccines contain _____________.
denatured bacterial exotoxins
-
Bacterin antibacterial vaccines contain __________, but they are less effective.
killed bacteria
-
___________ are critical to help boost the immune response with non-live vaccines.
Adjuvants
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3 ways that adjuvants help boost the immune response to a vaccine.
slow removal of Ag, enhance Ag presentation, and stimulate TLR responses
-
What are the core vaccines for dogs?
parvo, distemper, adeno-2, rabies
-
What are the core vaccines for cats?
pankleuk, herpes, calicivirus, rabies
-
What are the typical vaccines given to horses?
tetanus, E/W EE, West Nile, Rabies
-
Maternal antibodies interfere with ___________; it declines around _________.
vaccines; 8-12 weeks of age
-
Normal proteins found on both normal and cancer cells.
tissue specific antigens
-
foreign proteins expresses on virally infected cancer cells.
viral antigens
-
proteins that normally are not expressed after fetal development that get "turned on" by cancer.
reactivated gene products
-
abnormal proteins.
mutated gene products
-
3 methods of active immunization as cancer immunotherapy.
chemically modified tumor cells, DNA vaccination, vaccination against oncogenic viruses
-
The melanoma vaccine use an _____________ to express human tyrosinase gene, which is needed for the first step of _______________.
E. coli plasmid vector; melanin production
-
Plasma cell neoplasia that is a solid mass.
plasmacytoma
-
Plasma cell neoplasia that is an infiltration in BM or extramedullary sites.
myeloma
-
Benign tumors of epidermal Langerhans cells that spontaneously regress.
histiocytoma
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Malignant proliferation of Langerhans cells, interstitial dendritic cells, or macrophages with marked cellular pleomorphism; erythrophagocytosis may be present.
histiocytic sarcoma
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