renin

is a hormonal system that plays a central role in the control of Na excretion and body fluid volume

is an enzyme secreted into the blood from specialized cells that encircle the arterioles at the entrance to the glomeruli of the kidneys

primary stimulus for increased renin secretion

decreased blood flow to the kidneys is caused by (2)

promotes secretion of aldosterone

other name of aldosterone

stimulates salt and water reabsorption by the kidneys and the constriction of small arteries which may cause increase in BP

less potent but significant regulatory effect on sodium excretion by the renal tubules

4 major types of drugs that act on the renal system

agents of choice for heart failure

drugs that block the enzyme that cleaves angiotensin 1 to form the potent vasoconstrictor angiotensin 2

receptor antagonists at the mineral corticoid receptor

results of aldosterone antagonist (2)

fomula for BP

agents that block aldosterone that may be used in the management of hypertension of HF