LAB Animal Research

  1. Who over sees the care and use of animals?
  2. What guidelines do the IACUC use?
    AWR and PHS
  3. If fluids are restricted how often must you way the animal?
    At least once a week (twice for rodents)
  4. What is a Micro and Macro environment?
    • Macro - Room
    • Micro - Kennel/Cage
  5. What is Thigomotactic, and what species prefers it?
    Mice: They prefer more wall space than floor space
  6. What is the lighting lux and noise dB max?
    325lux and 85dB
  7. At what temp will food start detreriate?
  8. why is cedar shavings looked down upon?
    emit aromatic hydocarbons that effect liver enzymes
  9. What two zoonotic diseases are from non-human primates?
    Filovirus and mcobacterial
  10. What intra-species disease is carried in rabbits?
    Bordetella brochiseptica
  11. Subclinical infections in rodents are? (5)
    Sendai virus, kilham rat virus, mouse hep virus, lymohocytic choriomeningitis virus, mycoplasma pulmonis
  12. Animal Room Doors measurements are...
    ~42in W and ~84in H
  13. Humidity levels should be where?
    30-70% with a 5% variation
  14. Lighting should be on what system in animal rooms?
    time-contolled diurinal lighting cycle
  15. What members are necessary fro the IACUC?
    Veterinarian, public member, and scientist
  16. IACUC acronym stands fro what?
    Institutional Animal Care Use Committee
  17. Animals adapt to extreme temps by what three methods?
    Physical, morphological, behavorial
  18. What kind of cage do rodents like?
    Solid bottom with bedding
  19. How many air changes per hour in an animal room?
  20. What animal helped determine illumination levels?
    albino rats
  21. What is susceptiable to animals due to high room illumination levels?
    Phototoxic retinopathy
  22. When should bedding changes not be performed?
    Pre- and Postpartum (child birth)
  23. How often should solid bottoms and accessories be sanitized?
    once a week for the cage and once every two weeks for accessories
  24. What is the effective temp range for a quality sanitation?
  25. What animal produces large amounts of proteins and minerals in their urine?
  26. Which type of rodent has high levels of homozygosity?
  27. Subclincial diseases are most common in what kind of rodents?
    conventionally housed
  28. What are corridor widths in facility?
    6x8 ft
  29. What should the floors be made of?
  30. What type of walls help eliminate noise?
  31. A Class-A dealer is....
    raise and sell purpose-bred species
  32. A class-B dealer is...
    provide random source animals
  33. How must dogs (and cats) be housed?
    Not outdoors, 45-85F, 6in higher than dogs tallest head [(L+6)^2/144=floor space]
  34. What is the temp range for the housing of guinea pigs and hamsters?
  35. What is the temp range for housing rabbits?
  36. What is the temp range for primates?
  37. When air transporting primates, what must the container label say?
    Live Animals: Wild Animals
  38. USDA and IACUC inspect how often?
    USDA, annually; IACUC, semiannually
  39. USDA tags do not have which of the following: USDA letter, state identifier, id number, date of birth.
    date of birth
  40. How do you id pus under 16 weeks?
    ear notching
  41. How long must pass before a USDA number can be reused?
    5 years
  42. What is the earliest a vet can do a health examination before transportation?
    10 days
  43. How long must an animal wait to be used in research when obtained by random source?
    5 days
  44. How often must dogs be exercised, or reviewed to exercise if exempted previously?
    Once a day; 30 days
  45. Minimal height for a guinea pigs cage is...
  46. Interior height of hamster cages must be at least how many inches?
  47. how long can temps exceed ranges before a deviation accurs?
    4 hours
  48. What is the minimum height for a rabbits cage?
  49. Rabbits sanitations are how many days before the next?
    30 days
  50. What is the max amount of rabbits in one inclosure while transporting?
  51. What does APHIS stand for?
    animal and Plant Health Inspection Service
  52. How many principles are there for animal research?
    9 Principles
  53. PHS policy mandates animal care programs to be in accordance with what three laws?
    AWA, the "Guide", and AVMA
  54. How often must an assurance report be done for the "Guide"?
    Every 5 years
  55. What is a category 1 institute?
    Accredited by the AAALAC and all facilities evaluated every 6 months
  56. What is the difference from a category 2 institute from a category 1?
    Evaluated by the institute, and most recent report submitted to assurance.
  57. How many members at lest does the IACUC need?
    5 members. One DVM, one scientist, and one public member
  58. What does the IACUC consider an animal facility?
    The holding of animals >24 hours
  59. Who shall the IACUC notice for approved/disapproved projects?
    the investigators and the institution
  60. If the IACUC suspends a project that was already approved who do they contact?
    IO and IACUC will review then send to OLAW
  61. How long must records be kept?
    3 years
  62. How often must IACUC report to OLAW
    At least every 12 months?
  63. What agencies does the PHS consist of?
    Substance abuse and mental health services, health resources and services, Indian health services, NIH, and CDC
  64. When exceptions to laws and guides, who must approve?
  65. How often must approved projects be reviewed?
    3 years
  66. Who bears ultimate responsibility for non clinical lab studies?
  67. Who is responsible for the overall conduct of a nonclinic study?
    Study Director
  68. What records are exempt from FDA inspections?
    QA Unit
  69. How long must raw data, records, and documentations be stored?
    10 years minimum
  70. Who is authorized to inspect a facility and records to be maintained?
    FDA and EPA
Card Set
LAB Animal Research
Basic Regulatory Information For Animal Research Laboratories.