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Total process where oxygen is supplied to and used by body cells and carbon dioxide is eliminated by means of gradients
Respiration
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Movement of gas in and out of alveoli
Ventilation
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Gas exchange occurs where?
Alveolar and capillary membranes
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When is equilibrium almost reached?
- Between blood in lungs and air in alveolus
- PO2 in blood almost equals PO2 in alveolus
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1 gram of hemoglobin capable of combining with how much O2?
1.36 mL O2
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What is the end product of glucose oxidation?
CO2
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During exercise CO2 is what?
Increased
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During anestheia production of CO2 what?
Decreased
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In the tissues, this reacts with CO2 and H2O to form carbonic acid
Carbon anhydrase
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Lobes of the lungs
- Apical lobe
- Cardiac lobe
- Accessory lobe
- Diaphragmatic lobe
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Inspiration causes the chest cavity to expand and creates what
Negative pressure and is an active process
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Passive process that is a natural recoil or elasticity of the expanded lung and chest wall
Expiration
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3 areas of pulmonary ventilation
- 1) Muscles
- 2) Movement of air
- 3) Plural pressure
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Lung expansion/contractions in regard to pulmonary ventilation
Muscles
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In/out movement of lungs and pressure that closes it in regards to pulmonary ventilation
Movement of air
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Changes during respiration in regards to pulmonary ventilation
Plural pressure
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Muscles that cause lung expansion/contraction
- 1) Abdominal muscles
- 2) Intercostal muscles
- 3) Diaphragm
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2 ways muscles cause lung expansion/contraction
- 1) Downward/upward movement of diaphragm to lengthen and shorten
- 2) Elevation/depression of ribs to increase and decrease the diameter of the chest cavity
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Layer of substance the lungs float in the thorax
Plural fluid
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Plural fluid designed to (2 things)
- 1) Prevent friction
- 2) Reduce heat from excess movement
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Anesthetics cause
- 1) Suppress respiration
- 2) Cardiovascular function
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Normal quiet breathing
Eupnea
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Labored breathing
Dyspnea
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Fast/deep respiration
Hyperpnea
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Rapid, shallow breathing, panting
Polypnea
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Cessation of breathing
Apnea
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Slow/shallow breathing
Hypopnea
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Long, gasping inspirations with several subsequent ineffective exhalations. Commonly seen with ketamine hydrochloride
Apneustic respiration
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Sequences of gasps, apnea, and deep gasps
Blot respiration
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Increase in rate and depth, becomes slower and followed by brief apnea
Cheyene-stokes respiration
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Regular, deep respirations without pause
Kussmaul respirations
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Concentration of oxygen attached to hemoglobin
SpO2
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Adequate delivery of O2
DO2
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Reduced O2 consumption
VO2
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Volume of gas passing into and out of the lungs in one normal respiratory cycle.
Tidal volume
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Volume of air that can be inspired over and above the normal tidal volume
Inspiratory Reserve Volume
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Amount of air that can be expired by forceful expiration after a normal tidal expiration.
Expiratory Reserve Volume
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The air remaining in the lungs after the most forceful expiration.
Residual Volume
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Describe the amount of gas moved per minute
Minute volume
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Minute volume formula
Respiratory rate X Tidal volume
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Contributes to gas exchange
Alveolar ventilation
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Little to no diffusion of oxygen and carbon dioxide through membranes of airways known as
Dead space
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When you breathe for an animal via respiratory bag, ambu bag, etc.
Positive pressure ventilation
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Increased CO2/decrease of CO2
Hyper/Hypocapnia
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SpO2 less than 95%
Desaturation
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PaO2 less than 100 mmHG on oxygen or a low observed minute volume
Hypoxemia
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Other causes for positive pressure ventilation
- 1) Surgery requiring open chest
- 2) Neuromuscular disease
- 3) Chest wall trauma
- 4) Abdominal enlargement
- 5) Pulmonary parenchymal disease
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Amount of air that a person can breathe beginning at the normal expiratory level and distending the lungs to the maximum amount.TV+IRV
Inspiratory capacity
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Amount of air remaining in the lungs at the end of normal expiration. ERV+RV
Functional residual capacity
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Maximum amount of air that a person can expel from the lungs after first filling the lungs to their maximum extent and then expiring to the maximum extent. IRV + TV = ERV
Vital capacity
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Maximum volume to which the lungs can be expanded with the greatest possible inspiratory effort. VC + RV
Total lung capacity
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Begins in the larynx (voice box). Two fibrous connective tissue bands called the vocal (vocal folds) stretch across the lumen of the larynx and vibrate as air passes over them.
Voice Production (phonation)
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Higher the Co2 the more what kind of environment and what ph?
Acid environment and lower the pH
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Lower the Co2 the more kind of enviornment and what pH?
Alkline environment and higher the pH
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Respiratory acidosis
- Lower pH
- Increased PaCO2
- Lungs cant get rid of CO2
- Hyperventilating
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Respiratory alkalosis
- Higher pH
- Decreased PaCO2
- Lungs releasing to much CO2
- Hyperventilating
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3 secondary functions of the respiratory system
- 1) Voice production
- 2) Body temperature regulation
- 3) Acid-Base balance
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Methods to maintain neutral pH
- 1) Blood buffers
- 2) Respiration
- 3) Kidneys
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Blood buffers
Body releases sodium bicarbonate from pancreas
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How kidneys help maintain neutral blood pH
Retains more positive ions like Na and excretes more negative ions like H and Cl
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Increase in H and CO2 ions
Metabolic acidosis
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Causes of metabolic acidosis
- Diarrhea
- Ketosis
- Infectious diseases
- Renal insufficiency
- Shocks
- Administration of acid drugs
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Increase in CO2 resulting from hypoventilation with retention of carbon dioxide.
Respiratory acidosis
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Body attempts to correct acidosis by increasing respiration by:
- 1) Remove CO2
- 2) Conserve bicarbonate ions
- 3) Excrete hydrogen ions
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Increase in O2 and sodium bicarbonate.
Metabolic alkalosis
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Causes of metabolic alkalosis
- 1) Vomiting
- 2) Corticosteroid overdose
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Body will attempt to correct metabolic alkalosis by slowing respirations by
- 1) Kidneys excreting bicarbonate ions
- 2) Retain hydrogen ions
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Increase in O2
Respiratory alkalosis
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Causes of respiratory alkalosis
- 1) Hyperventilation
- 2) Abnormally low loss of CO2 as compared to O2 inhalation
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Occurs all over the body, exchange of O2 and CO2 between the blood in the capillaries, cells and tissues. Business end of respiration
Internal respiration
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Passage of gas from alveoli to RBC
- 1. Surfactant lining the alveoli is a phospholipid produced by the inner lining of the alveoli
- 2. Alveoli Epithelium
- 3. Capillary Endothelium (simple squamous) intercellular clefts.
- 4. Plasma
- 5. Red Blood Cell Membrane
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Normal activity consumes about 25% of the normal 20 mL/dL of the oxygen circulated as blood is circulated to tissues. 25% value knows as
Utilization Coefficient
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Central respiratory centers located where
Medulla and pons
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Concentrations of O2 and CO2 at aortic arch and carotid sinus
Peripheral Chemoreceptors
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Measuring blood pressures at aortic arch and carotid sinus
Peripheral pressoreceptors
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Cardioinhibitory center and Vasomotor center are in direct nervous contact with the
Carotid sinus, aortic arch, lungs at the bifurcation of the trachea via the glossopharyngeal nerve and vagus nerve
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Chemoreceptors generally respond to O2 and CO2 concentrations to do what with respiration
Increase respirations
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Pressoreceptors generally respond to blood pressures to do what with respiration
Inhibit respirations
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Carotid Sinus location of pressoreceptors and chemoreceptors
Bifurcation of the carotid artery to form the internal carotid arteries
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Aortic body location of pressoreceptors and chemoreceptors
Lesser curvature of the aorta
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