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What agents cause dec libido/hormonal alterations?
Lead, mercury, manganese, carbon disulfide
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Agents that cause sperm toxicity
Lead, DBCP, carbaryl, toluenediamine, dinitrotoluene, ethylene dibromide, stryene, acetone, ethylene glycol, monoethyl ether, welding, perchloroethylene, mercury, heatt, military radar, kepone, bromine, radiation,
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Agents that cause spontaneous abortion in female partner
Solvents, lead, mercury
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Males: agents that cause congenital malformations in offspring
Pesticdes, chlorophenates, solvents
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Males: agents that cause neurobehavioral disorders in offspring
Alcohols,cyclophosphamide, ethylene bromide, lead, opiates
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Males: agents that cause cancer in offspring
Solvents, paint, pesticides, petroleum products
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Pregnancy effects: heavy metals
Neuro and behavioral defects
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Effects in pregnancy: organic solvents
Ab, inc risk in birth defects, fetal solvent syndrome
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Pregnancy effects: antineoplastic agents:
Spont ab
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Pregnancy effects: antivirals
Ab, sperm effects in maoes, teratogenesis in females
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Pegnancy effects: estrogenic/antiestrogenic compounds
Ab, sperm effects in males, teratogenic effects in females
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Pregnancy effects: immunosuppressives
Ab, sperm effects in males, teratogenesis in females
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Aluminum: systems affected
Nervous, respiratory
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Arsenic: systems affected
Nervous, liver, GI, resp, hematopoietic, endocrine
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Cadmium: systems affected
Renal, nervous, GI, resp, bone, CV
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Chromium: systems affected
Renal, nervous, liver, resp, skin
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Cobalt: systems affected
Nervous, GI, resp, endocrine, skin, CV
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Copper: systems affected
GI, hematopoietic
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Effect on pregnancy: carcinogens/mutagens
Males: sperm effects, offspring of exposed females: teratogenesis, cancer
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Effect on pregnancy: waste anesthetic gases
Ab
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Effect on pregnancy: sterilants and disinfectants
Ab
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Effects on pregnancy: PCBs
Congenital PCB synd, mild neonatal growth/behavioral effects
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Effects on pregnancy: pesticides
Male and female reproductive effects
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Flouride: systems affected
Nervous, resp, bone, skin
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Iron: systems affected
Nervous, liver, GI, resp, HP, endocrine
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Lead: systems affected
Renal, nervous, HP, endocrine
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Manganese: systems affected
Nervous, resp
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Mercury: systems affected
Renal, nervous GI, resp
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Nickel: systems affected
Nervous, resp, skin
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Selenium: systems affected
Renal, GI, skin
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Silver: systems affected
Resp, skin
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Thallium: systems affected
Renal, nervous, liver, GI, resp, bone
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Zinc: systems affected
GI, HP, bone
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Chemicals that cause infertility
Anesthetics, cadmium, chloroprene, ethylene dibromide, lead, manganese
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Agents that cause menstrual disorders
Aniline, benzene, carbon disulfide, chloroprene formaldehyde, lead, toluene
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Agents that cause female fecundity
Mercury
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Agents that cause prematurity/low birth weight
Cadmium, CO, formaldehyde, mercury. toluene. vinyl chloride
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Agents that cause birth defects
Antineoplastics, benzene, lead
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Agents that contaminate breast milk
Benzene, cadmium, DDT, dieldrin, lead, mercury
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Hazards related to abrasive blasting
Silica and metal dust
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Hazards related to cosmetology
Chemical exposures
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Hazards related to farming
Pesticide exposures, heat illness, heavy lifting, hazardous equipment
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Hazards related to grinding, polishing and buffing
Toxic dust inhalation (metals, abrasives)
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Hazards related to painting
Solvent inhalations
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Hazards related to meat wrapping
Ortho (standing/lifting) fume exposure from wrap
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ANSI work type classifications
- Struck by
- Caught in, under, between
- Struck against
- Fall from height
- Fall on same level
- MVA
- Overexertion
- Repetitive trauma
- Other causes physical trauma (electric current, radiation, temperature extremes, chemicals, tissue abrasions)
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Marker model: activities that constitute professional practice
- 1. Establishing standards for prof. practice
- 2. Credentialling (licensure, performance monitoring, certification and testing)
- 3. CE
- 4. Performance appraisals compared to established standards
- 5. Audit procedures and data collection
- 6. Monitoring for a quick check of quality of care
- 7. Ongoing problem identification and monitoring
- 8. Resource utilization monitoring
- 9. Continuous risk management
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Four specialty areas of ergonomics
- Human factors engineering: gauges, warding buzzers, signs, instructions, controls
- Anthropometry: design of clothing, machines, furniture and tools
- Occup. biometrics: studies effects of work on muscles/connective tissues and devleopement of M-S disorders
- Work physiology: deals with ways work affects the CVS, resp system and skeletal muscles with goal of preventing body fatigue
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Raynaud's syndrome:
Cause
Symptoms
- Vibration
- Numbness, tingling, ashen skin, loss of feeling and control
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Four aspects of an ergonomic program
- Worksite analysis
- Hazard prevention and control
- Medical management
- Training and education
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Administrative controls: meaning
Policies/procedures; do not remove hazards, but attempt to control it
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Rotator cuff tendintis:
Cause
Symptoms
- Working with hands over head
- Shoulder pain and stiffness
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Carpal tunnel syndrome:
Symptoms
Cause
- Tingling, numbness, loss of sensation, pain in thumb, IF, MF half of RF
- Repetitive/forceful manual tasks
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De Quervain's Disease: cause
Excessive twisting/gripping
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Definitions:
Carcinogenic
Initiation
Promotion
- Has potential to cause cancer through:
- Initiation (genetic mutations occur)
- Body can repair/prevent cancer@this point
- Promotion (changes are stimulated to be cancer)
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Dose-response:
Effective
Threshold
- Correlation between dose and effect
- Effective: positive therapeutic effect
- Threshold: dose at which drug begins to have an effect
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Latency period
Time between moment of exposure to a chemical and when an observable effect is realized
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Definition: toxic vs. hazard
Toxic: has potential to cause harm to organism
Hazard: potential for damage is severe enough that it can result in poisoning
Thus, every toxic chemical is not necessarily toxic. Toxicity cannot be altered, but safe work practices can control hazards.
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Definition:
Poisontoxin
- Poison: chemical that produces illness or death when a person is exposed to only small quantities
- Technically: chemical with an LD50 of 50 mg or less per kg of body weight. The lower the LD50, the great the toxicity
Toxin: chemical that produces a negative effect.
All poisons are toxins, but not all toxins are poisons
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Asphyxiants: simple/chemical
Simple: displace oxygen in the air (carbon dioxide)
Chemical: block absorption of oxygen in body at cellular level: eg carbon monoxide
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3 sources that dictate classification as a substance as a hazard
- 1. Scientific literature/exposure limit guides
- TLVs (threshold limit values) published by American Conference of Govt. Hygenists (ACGIH)
- 2. Legal requirements: OSHA, federal, state, and local regs
- 3. Data gathered from worker evaluatons: work process assessment, worksite assessment, biological sampling and environmental sampling
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Integrated sampling
Active/passive sampling
- Integrated sampling: moves known volume of air through filter over a specific period of time
- Active: air physically forced through filter using a sampling pump
- Passive: Air is not mechanically forced through filter, but allowed to pass at natural rates as by diffusion
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Mutagenic effect
One that results in change (mutation) to the DNA of organism
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Threshold limit value-time weighted average (TLV-TWA)
Time-weighted avg concentration that all workers are exposed to during a normal 40-hr work week and to which no negative effects are observed. Typical, consistently repeated exposure that produces to harm to workers
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Theshold limit value-short term exposure limit (TLV-SEL)
Concentration workers can be exposed to continuously over a short period of time where no noticeable negative effects are observed.
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Threshold limit value-ceiling (TLV-C)
Concentration considered top, threshold limit. exposure level at which noticeable and negative effects are realized. Should never be surpassed.
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Grab sampling
Uses container to collect a sample of air which is analyzed for concentration of contaminants. Instant, point in time assessment, so NOT best technique for assessing exposure levels throughout day. Used if you want to determine contaminant levels at a time when it is known that levels are high
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Information required in MSDS
- -Name of material per label
- -Chemical and common name of all ingredients
- -Physical and chemical characteristics of every hazardous ingredient
- -Physical hazards of chemicals
- -Health hazards of chemicals including signs and symptoms of exposures and health conditions that can be made worse by exposure
- -Primary routes of entry
- -Exposure limits
- -Carcinogenic status
- -Necessary control measures
- -Precautions for safe handling
- -Emergency and first-aid measures
- -Date of preparation of MDSS
- -Contact information of all parties responsible for preparaton of MDSS
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Ranking system for acute chemical toxicity
- Classification/Lethal Dose for adult/Example
- 1. Practically nontoxic: >15 -15g/kg (more than one quart-sugar)
- 2. Slightly toxic: 5-15 g/kg (one pint to one quart-salt)
- 3. Moderately toxic: .5-5 g/kg (one ounce to one pint 2,4-D herbicide)
- 4. Very toxic: 50-500 mg/kg (one tbsp- one oz-arsenic acid)
- 5. Extremely toxic: 5-50 mg/kg (7 gtts to one tsp-nicotine)
- 6. Supertoxic: <5 mg/kg (<7 gtts-botulin toxin)
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Biological Exposure Indices (BEIs)
- Provide a measurement to which results of biological monitoring tests can be compared
- Provide warning of exposure and not an indication of the negative effects of a substance
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Occupational Health and Safety Act
- 1970
- Excludes: self-employed, farms that don't employ outside help and industries regulated by other federal agencies
- Created OSHA
- Companies can be inspected at any time without advance notice
- Created NIOSH which performs and funds OH and safety related research
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Family Medical Leave Act:
year/how much leave/employee notice
1993
Up to 12 weeks of unpaid leave within a year without demotion or losing job
Employee must give 30 days leave whenever possible
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FMLA: Valid reasons
- Birth and care of a child
- Adoption or foster placement of a child
- Care of a parent, spouse or child with serious health condition
- Worker's own ability to work due to a serious health condition
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FMLA: 2 qualifying conditions
- Work for employer has at least 50 workers within a 75 mi radius
- Must have worked for 12 months for at least 1250 hours
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Knowles four principles of adult education
- Independent learning: give them self-directed activities
- Previous experience: use learner's experience as a base
- Readiness to learn: take advantage of moments when learners are receptive to information (pregnancy, diagnosis with illness)
- Problem-oriented learning: address the specific concerns and problems of the learner, making learning experience relevant and specific
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Ways to categorize epidemiologic data
- a: number of individuals exposed who have the diseae
- b: number of individuals exposed who do NOT have the disease
- c: Number of individuals unexposed who have the disease
- d: Numbers of individuals unexposed who do NOT have the disease
- Total number exposed: a+b/Total number unexposed: c+d
- Total number with disease: a+c/Total number without the disease: b+d
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Relative risk
- Disease rate in exposed/disease rate in unexposed
- a/(a+b) / c/(c+d)
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Levels of prevention
- Primary: eliminating or reducing risks
- Secondary: early detection and initial management
- Tertiary: after disease is detected and is irreversible, rehab and return to optimal level of health within confines of disease
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Tort
Wrong committed against a person or their property: fraud, invasion of privacy, defamation
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Nursing Negligence:
Actions that compromise the standard of care to which all nurses are supposed to be committed
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Malpractice
Neglect of a patient due to unprofessional conduct or lack of skill
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OSHA recordkeeping requirements
Applies to employers with more than 11 employees
Recorded in OSHA 300 log
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What must be recorded in OSHA 300 log
- Injuries that result in :
- Death
- Missed days of work
- Job restrictions
- LOC
- Serious injuries or illnesses that are diagnosed by a physician or those that require major medical treatment
- Needlesticks/HBBF exposure
- Privacy cases must also be reported
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Epidemiological triad
Host, agent, environment
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OSHA access to employee exposure and medical records standard
- Standard requires that the worker or a delegated rep must have access to the occ health records
- Provided without charge within 15 days
- Requires signed consent: which records, purpose of the release, to whom they are being released, date, authorization time period, authority by which records are being requested and identification of the employe
- Not allowed to take originals
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Worker's comp: benefits
- Income replacement for time ee is unable to work
- Support for dependents in case of work-related death
- Hospital, medical and funeral expenses
- In some cases, related travel and parking expenses
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Workers comp: conditions
- Must be provided whether or not accident was a result of employee neglect
- If accepted, employee no longer to seek legal action against employer
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ADA: definition of disabled
Have a physical or mental condition that limits their ability to participate in life activties
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ADA: provisions
- Applies to employers with more than 15 employees
- Cannot deny an individual a job because of disability
- Persons with disabilities must be provided with reasonable accomodations
- EEOC enforces
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Disease frequency
Number of events/Number of people at risk X population constant k
Usually reported per 100,000
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Periods of development in perinatal toxicology
- Implantation (6-7 days): embryonic death
- Organogenesis (7 days-2 mos): birth defects
- Embryonic period (0-3 mos): birth defects
- Fetal Period (3-9 mos): developmental and behavioral deficits, endocrine and immune dysfunction, cancer
- Neonatal period (after birth): functional defects
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ANSI: 5 different types of chemicals
- Dusts: solid particles that result from physical processes, like handling, crushing, grinding
- Fumes: solid particles that result form condensation of gases or due to chemical reactions like oxidatin
- Mists: drops of liquid that are suspened in the air due to the change of a gas to a liquid or by dispersing a liquid by splashing or foaming
- Vapors: the gaseous state of a liquid that is commonly found in its solid or liquid state
- Gases Fluid that tend to stay in the gaseous state and can only changed into a liquid or solid state by a combination of increasing pressure and decreasing temperature
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Permissable exposure limits (PEL)
- OSHA publishes
- Based on TLVs developed by ACGIH
- PELs not updated as frequently as TLVs, so TLVs may be more accurate/updated
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Recommended exposure limits: RELs
- Published by NIOSH
- Time weighted for up to a 10 hour day of a 40 hour workweek
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