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Any abnormal change in the function or structure of the body as a result of some type of injury
Disease
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the study of disease processes
pathology
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sequence of events producing cellular changes that lead to observable changes known as manifestations
pathogenesis
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how a disease presents itself
manifestation
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The patient's perception of the disease that has subjective manifestations
symptom
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an objective manifestation that can be detected by the physician during examination
sign
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a group of signs and symptoms that characterizes a specific abnormal disturbances
syndrome
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the study of the cause of a disease
etiology
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no cause for disease can be identified
idiopathic disease
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disease that is acquired from the environment of the hospital
nosocomial disease
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adverse responses that occur from medical treatment itself
iatrogenic disease
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a disease that has a quick onset and lasts a short period of time
acute disease
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a disease that occurs more slowly and lasts a very long time
chronic disease
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name of the disease
diagnosis
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the prediction of the course and outcome of the disease
prognosis
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lasting side effects from having an acute illness
sequelae
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the structure of cells or tissue
morphology
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a disease process in which there is decrease in body tissue density
destructive, lytic, subtractive
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body tissue is altered by increasing the normal tissue density
additive, sclerotic
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investigation of disease in large groups
epidemiology
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the number of cases of a disease found in a given population
prevalence
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the number of new cases of a disease found in a given time period
incidence
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diseases of high prevalence in an area where a given causative organism is commonly found
endemic
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excessive prevalence or an outbreak of disease in the same geographical area
epidemic
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a widespread epidemic, that is, a disease or outbreak that affects very high proportions of the populations throughout the world.
pandemic
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the number of deaths caused by a particular disease averaged over a population
mortality rate
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the incidence of sickness sufficient to interfere with an individuals normal daily routine
morbidity rate
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tracks, monitors, and reports trends in health and aging.
responsible for trending morbidity rate.
- center for disease control and prevention
- CDC
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collects death certificates from each state and publishes information on mortality statistics and trends
- national center for health statistics
- NCHS
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monitors and reports mortality rates in terms of leasing cause of death, according to sex, race, age, and specific causes of death such as heart disease or breast cancer
NCHS and DHHS (Dept. of health and human services)
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an international coding system or standard diagnostic classification system used to report causes of death
-classify diseases and other health problems
ICD-10
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Leading causes of death in the U.S
- Chronic diseases:
- heart disease and malignant neoplasms
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over the past nine years,mortality rates for cancer, heart disease and HIV have
declined
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mortality rates for diabetes mellitus and Alzheimers has
risen
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ages 1-44 leading cause of death
injury
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the total value of goods and services produced in a country over a period of time
gross domestic product
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goals of the human genome project (1990-2003)
- identify all 20,000 to 25,000 genes in human dna
- determine sequences of the three billion chemical base pairs in dna
- store info in data bases
- transfer relates technologies to the private sector
- address the ethical, legal, and social issues of the project
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generalized decrease in cell size
atrophy
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generalized increase in cell size
hypertrophy
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absence of tumor cell differentiation, loss of cellular organization
anaplasia
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an increase in the number of cells in tissues as a result of excessive proliferation
hyperplasia
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conversion of one cell type into another cell type that is not normal for that tissue
metaplasia
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abnormal changes of mature cells
dysplasia
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six disease classifications
- congenital and hereditary
- inflammatory
- degenerative
- metabolic
- traumatic
- neoplastic
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present at birth
-genetic or environmental causes
congenital
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developmental disorders passed down from parents and acestors
hereditary
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results from the body's reaction to a localized injurious agents
inflammatory disease
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three types of inflammatory diseases
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from invasion by microorganisms such as viruses, bacteria or fungi
infective disease
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results from poisoning by biologic substances
toxic disease
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are an overreaction of the body's own defenses
allergic disease
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antibodies are formed and act against and injure the patients own tissues
- autoimmune disorders
- lupus, rheumatoid arthritis
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removal of dead cells and materials
debridement
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an inflammatory process caused by a disease causing organism
infection
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inflammation cannot occur without
infection
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refers to the ease with which and organism can overcome the body's defenses
virulence
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the function or structure of the tissue deteriorates
degenerative
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the physiologic processes reach a peak, and gradually fade until the body cant survive
aging process
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factors affecting the aging process
- heredity
- diet
- environmental
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diseases common with aging
- atherosclerosis
- osteoporosis
- osteoarthirits
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disease caused by a disturbance of the normal physiologic function of the body
metabolic disease
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the sum of all physical and chemical processes in the body
metabolism
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metabolic functions are regulated by
hormones secreted by endocrine glands
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the most common disturbance of fluid balance
insufficient intake of water or excessive loss of water
dehydration
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caused by mechanical factors, effects of ionizing radiation, or extreme hot or cold temperatures
traumatic disease
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an injury of soft parts associated with rupture of the skin
wound
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bleeding into the tissue spaces as a result of capillary rupture
bruise or contusion
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caused by alterations in cell growth, resulting in new abnormal tissue growth
neoplasm, tumor
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do not necessarily become malignant but can be life threatening
remain localized and are generally noninvasive
benign neoplasm
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continue to grow, spread, and invade other tissues
-exhibits loss of control of both cell proliferation and cell differentiation, changing its functional capabilites
malignant neoplasm
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a general term denoting various types of malignant neoplasms
cancer
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refers to the process of cellular specialization
-difference between new cells and original cells is small
-low probability of malignancy
differentiated
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cells have atypical characteristics and have a high probability of malignancy
undifferentiated
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affecting blood and lymph
hematologic
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the spread of cancer cells
metasesis
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the spreading of cancer cells by the blood system
hematogenous spread
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the spreading of cancer cells by the lymphatic systems
lymphatic spread
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the lymph node the primary neoplasm drains
sentinel node
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the spreading of cancer cells into the surrounding tissues because of close proximity of the area
invasion
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cancer cells travel to a distant site or distant organ system
seeding
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the many types of cellular change that can occur in response to disease
lesion
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one type of cancer and is derived from epithelial tissue, not the same as the general term cancer
carcinoma
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a cancer which arises from connective tissues
sarcoma
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cancer that arises from blood cells
leukemia
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cancer that arises from lymphatic cells
lymphomas
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treatment allows the patient to remain free of disease for five years or more
curative
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treatment that is designed to relieve pain when curing is not possible
palliative
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a classification used to determine the appropriate treatment of cancer and to help in determining prognosis
TNM system
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T stands for and is measured how
- size of the untreated primary cancer
- T0-T4
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N stands for and is measured how
- lymph node involvement
- N0-N3
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M stands for and is measured how
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