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Functional Class
Electrolyte
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Mechanism of Action
- Calcium channel blocker
- Blocks neuromuscular transmission
- CNS depressant effective in seizures associated with eclampsia or pregnancy
- Decreases amount oc ACh liberated from motor nerve terminals
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Contraindications
- Heart Block
- Shock
- Persistent hypertension
- Hypocalcemia
- Myocardial damage
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Precautions
- Renal failure
- Digoxin
- Other CNS depressants
- Neuromuscular blocking agents
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Side Effects
- Hypotension
- Sedation
- Confusion
- N/V
- Bradycardia
- Pruritis
- Arrythmias
- Decreased deep tendon reflexes
- Respiratory depression/paralysis
- Drowsiness
- Muscle weakness
- Complete HB
- When used prior to delivery it can cause fetal hypoxia, asphyxia, arrhythmias, and fetal intracranial bleeding
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Interactions
Can cause cardiac conduction abnormalities when used with digitalis
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Dose and Route
- Eclamsia: 2-4 grams slow IVP in 10mL NS over 5 mins
- Torsades: 1-2 grams IVP diluted in 10 mL NS
- Asthma: 2 grams slow IVP in 100 mL NS over 10 mins
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Note
Calcium chloride can be used as an antidote
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