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What are Lewy bodies composed of?
Composed of a-synuclein intracellular eosinophilic inclusion
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Composed of a-synuclein intracellular eosinophilic inclusion
Lewy bodies
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Chromosome number associated with Huntington disease?
Chromosome 4
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Which neurotransmitters are affected in Huntington disease?
Decreased levels of GABA and ACh in the brain.
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Intention tremor Slow, zigzag motion when pointing/extending toward a target is due to which disease?
Cerebellar dysfunction
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How do neurons die in Huntington disease?
Neuronal death via NMDA-R (N-methyl-D aspartate - R) binding and glutamate toxicity.
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What part of the brain undergoes atrophy in Huntington Disease?
Atrophy of caudate nuclei
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A lesion to the Right parietal-temporal cortex results in?
Spatial neglect syndrome (agnosia of the contralateral side of the world)
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A lesion to the Left parietal-temporal cortex results in?
- Agraphia, acalculia, finger agnosia, and left-right disorientation
- Gerstmann syndrome.
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A lesion to the Reticular activating system (midbrain) results in?
Reduced levels of arousal and wakefulness (e.g., coma)
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A lesion to the Basal ganglia results in?
- Tremor at rest, chorea, or athetosis.
- Parkinson disease.
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Damage to the cerebellum results in?
Ipsilateral deficits; fall toward side of lesion
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Damage to the Cerebellar vermis results in?
Truncal ataxia, dysarthria (difficulty saying words because of muscle problems)
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A lesion to the Subthalamic nucleus results in?
Contralateral hemiballismus
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A lesion to the Hippocampus (bilateral) results in?
Anterograde amnesia inability to make new memories
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What happens in a lesion to the Paramedian pontine reticular formation?
Eyes look away from side of lesion
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What happens in a lesion to the Frontal eye fields?
Eyes look toward lesion
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