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Dysplasia and carcinoma in situ are associated with which viruses and gene product?
- Associated with HPV 16 and HPV 18, which produce both the:
- 1. E6 gene product (inhibits p53 suppressor gene)
- 2. E7 gene product (inhibits RB suppressor gene)
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What is the mechanism of the E6 gene product in cervical dysplasia and carcinoma in situ?
inhibits p53 suppressor gene
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This gene product of HPV 16 and 18 inhibits p53 suppressor gene.
E6
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This gene product of HPV 16 and 18 inhibits RB suppressor gene.
E7
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What is the mechanism of the E7 gene product in cervical dysplasia and carcinoma in situ?
inhibits RB suppressor gene
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Where are Koilocytes found? Describe what it looks like.
Wrinkled, “raisinoid” nuclei, some of which have clearing or a perinuclear halo.
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What are the complications Invasive carcinoma?
Lateral invasion can block ureters, causing renal failure.
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Describe the clinical presentation of Endometriosis.
- Cyclic pelvic pain
- Bleeding
- Dysmenorrhea (painful menustration)
- Dyspareunia (painful intercourse)
- Dyschezia (pain with defecation)
- Infertility
- Normal-sized uterus
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What is Adenomyosis?
- Extension of endometrial tissue (glandular) into the uterine myometrium.
- Caused by hyperplasia of the basalis layer of the endometrium.
- PRESENTATION: Dysmenorrhea, menorrhagia. Uniformly enlarged, soft, globular uterus
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Extension of endometrial tissue (glandular) into the uterine myometrium is?
Adenomyosis- Caused by hyperplasia of the basalis layer of the endometrium.
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Uniformly enlarged, soft, globular uterus is characteristic of?
Adenomyosis
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What is Adenomyoma (polyp)?
- Well-circumscribed collection of endometrial tissue within the uterine wall.
- May contain smooth muscle cells.
- Can extend into the endometrial cavity in the form of a polyp.
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Whorled pattern of smooth muscle bundles with well-demarcated borders is characteristic of?
Leiomyoma (fiboid)
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Describe a Leiomyoma.
Whorled pattern of smooth muscle bundles with well-demarcated borders.
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In this disease, patients present with signs of menopause after puberty but before age 40.
- Premature ovarian failure
- Decreased estrogen, increased FSH and LH
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