-
Muromonab-CD3
- Type: 100% mouse
- Directed against: CD3 of T lymphocytes
- Function: Reduces T lymphocytes and CD3 expression on T lymphocytes
- Use: Prevent organ graft rejection by or depletes T cells prior to BM transplant
-
Abciximab brand name is:
Centorex, Reopro
-
Centorex, Reopro generic name is:
Abciximab
-
Abciximab (Centorex, Reopro)
- Type: Chimeric
- Directed against: Glycoprotein (GP) IIb/IIIa receptors = integrin family of adhesion molecules
- Function: inhibits monocyte and platelet adhesion through steric hindrance of the receptor, inhibits pro-coagulation vitronectin receptors and proliferation of endothelial and smooth muscle cell
- Use: Antithrombotic, ED MI
-
What is the brand name for Palvizumab:
Synagis
-
What is the generic name for Synagis?
Palvizumab
-
Palvizumab (Synagis)
- Type: CDR grafted/Humanized/Human like
- Directed against: RSV
- Use: Serious LRTI caused by respiratory syncytial virus (RSV)
-
What is the brand name for Adalimumab?
Humira
-
What is the generic name for Humira?
Adalimumab
-
Adalimumab (humira)
- Type: 100% human
- Directed against: TNF alpha
- Function: Blocks TNF-a interaction with p55 and p75 cell surface TNF-a receptors, decreases acute phase proteins, serum cytokines, and metalloproteinase
- Use: w or w/o methotrexate which reduces its clearance, to fight Adult and Juvenile Rheumatoid arthritis, Crohn’s disease, psoriatic arthritis and spondylitis
-
What are the functions of TNF alpha?
- Mediator of inflammation
- Endothelial cells = will increase the expression of adhesion molecules
- Increases the adhesiveness of PMNs to adhesion molecules
- Activates inflammatory cytokines and leukocytes
- Stimulates production of TNF alpha itself, IL-1 and IL-6
- Release of chemokines
- Causes acute phase response or the production of acute phase proteins
-
What is the brand name for Infliximab?
Remicade
-
What is the generic name for Remicade?
Infliximab
-
Infliximab (Remicade)
- Type: Chimeric
- Direct against: TNF alpha
- Function: Stops release of IL-1 and IL-6 (and other TNF-alpha effects), suppresses the expression of adhesion molecules, reduces inflammation and the acute phase response
- Use: rheumatoid arthritis and Crohn’s Disease
-
What is the brand name for Golimumab?
Simponi
-
What is the generic name for Simponi?
Golimumab
-
Golimumab (Simponi)
- Type: 100% human
- Direct against: TNF-alpha
- Use: Monthly treatment for moderate to severe rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and ulcerative colitis in patients not taking taking abatacept, kineret, or other TNFa blockers
-
What is the brand name for Certolizumab?
Cimzia
-
What is the generic name for Cimzia?
Certolizumab
-
Certolizumab (Cimzia)
- Type: CDR grafted/Humanized/Human like
- Direct against: membrane-bound and soluble human TNFα
- Function: Dose dependent neutralization of TNF-a without antibody-dependent cellular cytotoxicity, complement activation, or apoptosis in T cells or macrophages
- Use: Rheumatoid arthritis and Crohn’s disease (other autoimmune off label)
-
What is the brand name for Natalizumab?
Tysabri
-
What is the generic name for Tysabri?
Natalizumab
-
Natalizumab (Tysabri)
- Type: CDR grafted/Humanized/Human like
- Direct against: alpha-4 integrin (adhesion molecule)
- Function: interferes with the cellular traffic (T cells crossing BBB) and antiinflammatory
- Use: multiple sclerosis and Crohn’s disease
-
What are the notable SE of Natlizumab (Tysabri)?
Progressive multifocal leukoencephalopathy (PML), which is an opportunistic infection caused by John Cunningham (JC) virus
-
What MAB causes progressive multifocal leukoencephalopathy (PML), which is an opportunistic infection caused by John Cunningham (JC) virus?
Natlizumab (Tysabri)
-
What is the brand name for Tocilizumab?
Actemra
-
What is the generic name for Actemra?
Tocilizumab
-
Tocilizumab (Actemra)
- Type: CDR grafted/Humanized/Human like
- Direct against: soluble & membrane bound IL-6 receptors
- Use: SQ q/ or w/o methotrexate for the treatment of moderate to severe rheumatoid arthritis and systemic juvenile idiopathic arthritis
-
What MABs are used with Methotrexate?
- Adalimumab (Humira)
- Tocilizumab (Actemra)
-
What is the brand name for Belimumab?
Benlysta
-
What is the generic name for Benlysta?
Belimumab
-
Belimumab (Benlysta)
- Type: 100% human
- Direct against: B-cell activating factor (BAFF or B-lymphocyte stimulator)
- Function: Inhibits B cell development and survival
- Use: Systemic lupus erythematosus
-
What is the Brand name for Daclizumab?
Zenapax
-
What is the generic name for Zenapax
Daclizumab
-
Daclizumab (Zenapax)
- Type: CDR grafted/Humanized/Human like
- Direct against: alpha subunit of IL-2 receptors
- Function: Inhibits IL-2 mediated activation of T cells
- Use: Immunosuppression for kidney transplantation
-
What is the brand name for Basiliximab?
Simulect
-
What is the generic name for Simulect?
Basiliximab
-
Basiliximab (Simulect)
- Type: Chimeric
- Direct against: Alpha subunit of IL-2 receptors (CD-25 antigen)
- Function: Inhibits IL-2 mediated activation of T cells
- Use: Immunosuppression
-
What MABs inhibit IL-2 mediated activation of T cells by targeting the alpha chain of the IL-2 receptor?
- Basiliximab (Simulect)
- Daclizumab (Zenapax)
-
What is the brand name for Efalizumab?
Raptiva
-
What is the generic name for Efalizumab?
Raptiva
-
Efalizumab (Raptiva)
- Type:
- Direct against: LFA-1 and ICAM-1
- Function: inhibits adhesion of T cells to other cell types by inhibiting the binding of LFA-1 (CD 11) to ICAM-1. Inhibition of T cell proliferation, cytokine release, migration and interaction with tissue-specific cells
- Use: Psoriasis
|
|