A linked series of chemical reactions that begins with a particular molecule and converts it into some other molecule (s) in a carefully defined fashion
metabolic pathway
Can be divided into those that convert energy from fuels into biologically useful forms and those that require inputs of energy to proceed
catabolism
Reactions that transform fuels into cellular energy
anabolism
Reactions that require energy
amphibolic pathway
Pathways that are either anabolic or catabolic, depending on the energy conditions in the cell
ATP
Nucleotide consisting of adenine, a ribose, and a triphosphate unit; active form complexed with Mg2+ or Mn2+; energy-rich molecule because its triphosphate unit contains two phosphoanhydride bonds
Nucleoside monophosphate kinase
Family of kinases that catalyze the phosphorylation of nucleoside monophosphate
Nucleoside diphosphate kinase
Enzyme that catalyzes phosphorylation of nucleoside diphosphates
Ion gradients
They exist across membranes and are produced by the oxidation of fuel molecules or by photosynthesis; they couple thermodynamically unfavorable reactions to favorable ones
NAD+
Accepts a hydrogen ion and two electrons, which are equivalent to a hydride ion; used for generation of ATP
FAD
Carries electrons and accepts two electrons and two protons
NADP+
Different from NAD in that the 2’-hydroxyl group of its adenosine moiety is esterified with phosphate; carries electrons for reductive biosynthesis
Vitamin A
Precursor of retinal, the light-senstive group in rhodopsin and other visual pigments and retinoic acid, an important signaling molecule
Vitamin C
Aka: ascorbate; acts as an antioxidant
Vitamin D
A metabolite of it is a hormone that regulates the metabolism of calcium and phosophorus
Vitamin K
Required for normal blood clotting
Oxdation-reduction reactions
Essential components of many pathways; useful energy is derived form oxidation of carbon compounds
Ligation reactiions
Form bonds by using free energy from ATP cleavage
Isomerization reactions
Rearrages particular atoms within a molecule to prepare the molecule for subsequent reactions
Group-transfer reactions
Transfer groups and are used to synthesize ATP
Hydrolytic reactions
Cleave bonds by addition of water
Lyases
Enzymes that catalyze the addition of functional groups to double bonds to form single bonds or remove functional groups form single bonds to make double bonds