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The study of the body defenses any systems responsible for the recognition and disposal of foreign (nonself) material.
Immunology
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A substance that can stimulate the production of antiobdies (immune response).
Antigen (immunogen)
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specific glycoproteins produced in response to an antigenic challenge.
Antibody (immunoglobulin)
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The ability of an antigen to stimulate an immune response.
Antigenicity
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The process of being protected against foreign antigens.
Immunity
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The Body stimulates an immune response and reacts with self-antigens in a manner similar to the destruction of foreign antigens.
autoimmunity
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the combining site or sites with which antibodies react.
Antigenic determinants
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the portion of a molecule that the body recognizes as an antigen. (makes contact with antigenic determinant)
epitope
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LMW molecules that can combine with anoter molecule to produce antibody response.
Hapten
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a molecule that when coupled with a hapten, renders the hapten immunogenic.
Carrier
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Soluble protein mediator is released by sensitized lymphocytes on contact with an antigen.
Lymphokine
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serum proteins that attach to a forewign substance and enhance phagocytosis.
opsonization
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a compound that enhances the immune response to the antigen by increaseing its size or length of survival in the circulation.
adjuvant
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tissue reaction to injury
inflammation
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immunogen is synonymous with:
antigen
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antibody combines __________ specifically with the antigen.
specifically
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five factors affecting antigenicity.
- foreignness
- degradability
- molecular weight
- structural stability
- complexity
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the degree to which an antigen is recognized as non-self by an immune system.
foreignness
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how does molecular weight affect antigenicity.
higher the molecular weight, better the molecule funtions as an antigen.
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how does complexity affect antigenicity.
more complex an antigen, more effective it will be.
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nucleated cells have many cell surface proteins antigens that readily provoke an immune response.
histocompatibility
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what does MHC stand for?
Major Histocompatibility Complex
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this is second to ABO antigens in influencing survival or rejection of transplated organs.
Histocompatibility
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antigens found in unrelated plants and animals which are identical or closely related. (Cross Reaction)
Heterophile
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genetically different individuals are referred to as:
allogenic
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auto antigens will stimulate:
auto antibodies
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this is based on the sequence of amino acids linked together by peptide bonds.
Antibody structure
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Antibodies have a ___ chain structure consisting of pairs of identical heavy and light chains that form a Y shape
four
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how many light and heavy chains are there per antibody molecule?
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what holds an antibody molecule together?
disulfide bond
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what are the five classes of heavy chains?
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what are the two classes of light chains?
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what is responsible for bence-Jones proteins found in urine of multiple myeloma patients?
Light chains
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antibodies can be cleaved into two or more fragments by enzymes _______ and ________.
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this antibody fragment is capable of antigen binding, and is made of one light chain and half of a heavy chain.
Fragment antibody binding (Fab)
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This portion of a cleaved antibody will crystallize, it contains only the constant region of the heavy chain.
Fragment Crystalline (Fc)
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the variable region is located where?
In the Fab portion
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what are the five classes of antibodies named for?
Their heavy chains (Mu, Gamma, Alpha, Delta, Epsilon)
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this is the major immunoglobulin in normal serum, it readily diffuses into extravascular spaces, and is capable of crossing the placenta.
IgG-Gamma
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how many subclasses of IgG are there?
four
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this antibody is 70%-75% of the immunoglobulin pool
IgG
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This immunoglobulin provides immunity to newborn
IgG
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although combined only to blood, this pentamer shaped immunoglobuln is the first antibody produced in an immune response.
IgM-Mu
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This immunoglobulin consists of about 10% of the immunoglobulin pool.
IgM
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what is the main function of IgM?
agglutination
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this is the predominant immunoglobulin in intestinal secretions, saliva, tears, and colostrum.
IgA- Alpha
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how many subclasses of IgA are there?
two
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this immunoglobulin has a monomer or dimer shape and is known as a secretor antibody.
IgA
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This immunoglobulin is less than 1% of the immunoglobulin pool and has no protective funtion.
IgD- Delta
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this immunoglobulin is seen in allergic reactions and parasitic infections.
IgE- Epsilon
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This Immunoglobulin binds to basophils and mast cells to mediate relase of histamines and heparin.
IgE- Epsilon
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This immunoglobulin facilitates phagocytosis and kills microbes
IgE
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what is the primary function of antibodies?
to bind antigens
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what is the chemical composition of an antibody?
glycoproteins
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This antibody subclass has the shortest halflife.
IgD
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This is the immunity generated by the production of antibodies in response to foreign antigen.
Active immunity.
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This is when antibodies are produced after infection
Active Natural
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Injection of live, killed or attenuated microorganisms or their antigens.
Active Artificial
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This is temporary immunity resulting from transfer of antibody from one individual to another.
Passive Immunity
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durring pregnancy IgG antibodies are passed from mother to fetus; antibodies are pressed in breast milk
Passive natural
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This type immunity occurs when a person in injected with gamma globulin.
passive artificial
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this type of immunity is moderated by the link between "T" lymphs and phagocytic cells.
Cell Mediated immunity
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cell mediated immunity is responsible for what four immunities?
- Contact sensitivity (poison-ivy)
- Delayed sensitivity (contact dermatitis)
- Immunity to viral and fungal antigens
- rejection of foreing tissue grafts
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this is the principle leukocyte associated with phagocytosis
neutrophil
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these are fixed or wandering cells.
moncyte/macrophage
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Cell mediated immunity is activated in response to ____________.
Lymphokines
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where do T lymphocytes occur?
thymus
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T lymphocytes are what percent of total lymphocytes?
60-80%
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what are the two subpopulations of T lymphocytes?
- suppressor/cytotoxic subset
- helper/inducer subset
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what cells produce lymphokines?
T lymphocytes
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supressors are what percent of T lymphocytes?
25-40%
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what is the function of suppressor T cells?
turning off "b" cells
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helper cells are what percent of lymphocytes?
50-70%
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what is the function of Helper cells?
- control production of antibodies by "B" cells
- activate suppressor cells
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this immunity results from the formation and release or antibodies into the blood stream.
Humoral Immunity
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what is the primary component of humoral immunity.
B lymphocytes
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where do B lymphs mature?
bone marrow
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B lymphocytes are what percent of total lymphocytes?
less than 15%
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B lymps mature into what?
plasma cells
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when do plasma cells produce antibodies?
after interaction between macrophages, T lymps, and B lymps
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in what phase of immune response are no antibodies detectable?
lag
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in what phase of immune response does antibody titer rise?
log
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in what phase of immune response does antibody titer stabilize
plateau
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in what phase of immune response does antibody titer decline?
decline
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in a primary response what is the first antibody class produced?
IgM
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what is a secondary response also know as?
anamenestic
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in a secondary response how is the time different?
shorter lag, longer plateau,more gradual decline
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in a secondary reaction how does the type of antibody differ?
IgG is dominant antibody
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are antibody levels higher in a primary or secondary response?
Secondary
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this is the body processes that occur to defend the body against foreign antigens?
Immunity
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what type of immunity are you born with that includes epithelial cells, skin pH, and phagocytosis?
Innate (nonspecific) Natural
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what type of immunity is considerd the first line of defense?
Innate (nonspecific) natural
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this type of immunity is acquired only after a specific antigen is encountered. it can be intra or extracellular.
Adapptive (specific or acquired)
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how long does active immunity endure for?
Life
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what is the antigen receptor for B cells?
IgG
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These cells are CD4 positive and produce lymphokines to stimulate other T cell populations.
T helper cells
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These cells are CD8 positive and inhbit the action of other T cells.
T suppressor cells
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There cells are CD8 positive and they secrete lymphotoxins to destroy cells recognized as foreign.
cytotoxic T cells
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these are protein messengers produced by cells.
cytokines
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what are the three phases of humoral immune response?
- antigen elimination
- primary response
- secondary response
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this cytokines inhibit viral replication
interferon alpha and beta
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these cytokines activate macrophages, NK cells, and stimuate B cells to produce antibodies.
Interferon gamma
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This is a group of 18 plasma proteins that are involved in three separate pathways of activation.
complement.
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what are the three compliment pahtways?
- classical
- alternate
- mannose-binding lectin (MBL)
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what five complement proteins are unique to the classic pathway
C1 (C1q, C1r, C1s), C4 and C2
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what three complement proteins are unique to the alternate pathway?
- Factor B
- Factor D
- Properdin
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what six complement proteins are used in all pathways?
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these control proteins are normally present to inhibit uncontrolled activation.
- C1 INH
- Factor 1
- Factor H
- C4 binding protein
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complement proteins are destroyed by heating serum to what temperature? for how long?
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what are the only antibodies that can activate complement?
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what are the three functions of Complement?
- Celly Lysis
- Opsonization
- Anaphylatoxins
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which pathway is the major system of activation for complement?
Classic
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what is the classic pathway activated by?
Antigen-antibody
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in the classic pathway, C1qrs are held together by what?
calcium
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in what complement pathway is activation not dependent on attaching to antibodies?
alternate pathway
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in what complement pathway does microbial and mammalian cell surfaces activate it? (bacterial, fungal, parasites, viruses)
alternate
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what protein does the alternate pathway begin with?
C3
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in what pathway does mast associated serine protease activate complement?
mannose binding lectin
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these act as controls in complement activation.
inhibitors and inactivators
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which inhibitor binds C1qrs
calcium
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which inhibitor is required for C3 convertase
magnesium
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what inhibitor blocks C1r and C1s activity?
C1 inhibitor
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which inhibitor competes with factor B to bind with C3b
Factor H
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which inhibitor inactivates C3b when bound to factor H
Factor I
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What inhibitor takes out calcium?
EDTA
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these cause the relase of histamine from mast cells and basophils?
Anaphylatoxins (C3a, C4a, C5a)
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what are the two opsonins?
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what are the three anaphylatoxins?
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what is the chemotactic factor?
C5a
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this induces and directs migration and accumulation of phagocytic cells.
chemotactic factor
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this inate body defense is an indicator of inflammatory process.
Acute Phase Proteins
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this acute phase protein is used to signal infection many hours before it can be confirmed by culture.
C reactive protein (CRP)
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what types of Hypersensitivity are humoral mediated?
types I, II, III
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what hypersensitivity reaction is cell mediated?
IV
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these are immediate-type hypersensitivities like hay fever.
type I
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these hypersensitivites are cytotoxic responses like HDN.
type II
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these hypersensitives are immune complex reactions.
type III
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these hypersensitivites are delayed type reactions such Tuberculin Skin Tests or contact dermatitis.
type IV
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this represents an immune systems ability to discriminate between self and non-self.
autoimmune disorders
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thes alter antigens allowing the body to recognize them as non-self.
exogenous factors
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this is a fibrosis in the skin and internal organs caused by Raynaud's phenomenon.
Progessive Systemic Sclerosis (Scleroderma)
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In this disorder auto antibodies cause marked atorphy and fibrosis of the islet cells causing insulin deficiency.
Insulin Dependent Diabetes Mellitus
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in this disorde a goiter is caused by an overstimulated thyroid gland. Exophathalmos (bulging eyes) is a common finding.
Grave's disease
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this is an idiopathic adrenal atrophy that is characterized by low serum coritsol and elevated corticotrophin levels.
addison's disease
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this disorder affects lacrimal, salivary, and other exretory glands.
Sjogren's syndrome
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autoimmune hemolytic anemias are classified into how many groups?
- four
- WAIHA
- CHAD
- PCH
- Drug induced
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This disorder is associated with antibodies reactive at warm temperature (37oC). In most cases the RBCs are coated with both IgG and complement.
Warm Autoimmune Hemolytic Anemia (WAIHA)
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this is the most common type of hemolytic anemia.
Cold Hemagglutinin Disease (CHAD)
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This disorder is characterized by cold reactive IgM when body temp falls to 32oC or below.
Cold hemagglutinin Disease (CHAD)
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This disorder was perviously associated with syphilis.
Paroxysmal Cold Hemoglobinuria (PCH)
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In this disorder IgG reacts with RBC's in cold parts of the body. complement binds to cells and at warmer temps the cells hemolyze.
Paroxysmal Cold Hemoglobinuria (PCH)
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in this disorder there is an increased distruction of platelets. May be caused by Sulfonamide or morphine.
Idiopathic thrombocytopenic purpura
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this is a disease of the CNS related to immune abnormalities.
Multiple sclerosis (MS)
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in this disorder anti-DNA antibodies are produced.
Systemic lupus erythematosus
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this disorder has been associated with IgM, IgG, and IgA.
Rheumatoid Factor (RF)
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