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Pandora320
on FreezingBlue Flashcards.
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Has the gastroprotective features
Prostocyclins
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Pain that cox-2 works on
Throbbing
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Cox2 inhibitor on the market
Celecoxib
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Most common complaint when using indomethacin
Frontal HA
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Not an NSAID
Acetominophin
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Only one that be administered IV or IM
Ketorolac
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Don’t give in 3rd trimester
Ibuprofen
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Contraindicated in pregnancy
Indomethacin
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Good for PDA
Indomethacin
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What kind of risk does naproxen carry
cardiovascular
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Protection and maintenance function. Cannot be induced. Cox 1 or Cox2?
1
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Proinflammatory and mitgenic effects. Can be induced
COX-2
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Given in a once daily dose
Nabumatone
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What initiates the prostaglandin cascade
Phospholipase A2
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Are prostaglandins stored? What does this mean for release?
No. in order for prostaglandins to be released they need to be synthesized
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Do anti-inflammatory NSAIDS block the effect or the number of inflammatory cells
Effect
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Inhibiting PGE2, causes what effect
Antipyretic effect
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Risk with long-term use of NSAIDs and acetaminophen
Hepatotoxicity
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Is there a chronic effect with aspirin chronic use
No
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Onset and efficacy of analgesic effects are comparable to morphine
Ketorolac
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Salycilic acid category drugs
Aspirin, diflunisal
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Delays partrition in 3rd trimester
Ibuprofen
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Which one causes irreversible cox inhibition
Aspirin
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10g can cause hepatotoxicity
Acetaminophen
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Most potent inhibitor of COX
Indomethacin
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Must be stopped 1 week before surgery and why
Aspirin. Increased INR time. Irreversibly acetylates COX and inhibits platelet synthesis of Thromboxane A2, which is required for platelet aggregation
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Which drug has poor antipyretic effects? Why?
Diflunisal. It can't penetrate the CNS well.
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No anti-inflammatory effect
Acetaminophen
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Proprionic acid derivative drugs
Ibuprofen, naproxen
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Cause of fatal poisoning in children
Aspirin
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Acetic acid drugs
Indomethacin, ketorolac, Nabumetone
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Cox2 inhibitor drugs
Celecoxib, rofecoxib
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Reason why rofecoxib/Cox2 have been pulled from the market (mechanism/pathophys)
By only impacting the COX-2 -mediated PGI2 prostacyclin, there is an imbalance between thromboxane A2 in the platelets and prostacyclin in the vascular wall, leading to a net prothrombotic state
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Removed from the market
rofecoxib
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May cause peptic ulcer disease or renal failure if used more than 5 days
Ketorolac
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Can only be used OTC for 10 days
Naproxen
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