Chapter 3

Metagenomic sequencing is when the DNA sequences of multiple organisms being analyzed as a single data set.

• 1. Reveals overall gene number
• 2. Estimate of the collective metabolic capabilities of the communitites

• 1. Half the human genome has repeating sequences.
• 2. 80% transcribed to RNA.
• 3. 1.2% of genome encodes for protein.
• 4. 23000 encode for protein
• 5. Small fraction of genome is unique to vertebrates.
• 6. Two randomly genomes differ in 1/1000.

Open reading frames are protein encoding genes, 23000.

Simply more complex genomes having more modules or domains.

The modules are expressed thorough alternate gene splicing leading to multiple ways of protein synthesis.

Domains are modules in the more complex genome of vertebrates that are expressed through alternate gene splicing and when the genes are processed they lead to different proteins.