problems w translation

  1. stalled ribosomes
  2. non-stop or truncated mRNA 
    - caused by...(2)
    - effects...(2)
    • defective transcription
    • mutation = no stop codon or read-through

    • nucleolytic degradation: 
    • - truncated proteins
    • - stalled ribosome
  3. truncated proteins are usually:
    non-functional, dominant negative phenotypes, toxic
  4. prokaryotic stalled ribosome rescue mechanism
    - structure & function
    • transfer-messanger RNA (tmRNA) - combo
    • - mimics tRNAAla = aminoacyl tRNA synthetase (aaRS) transfers Ala
    • - middle of tmRNA has short (10aa) peptide used to tag truncated proteins for degradation
Author
chartreuse
ID
289770
Card Set
problems w translation
Description
translation problems
Updated