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problems w translation
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stalled ribosomes
non-stop or truncated mRNA
- caused by...(2)
- effects...(2)
defective transcription
mutation = no stop codon or read-through
nucleolytic degradation:
- truncated proteins
- stalled ribosome
truncated proteins are usually:
non-functional, dominant negative phenotypes, toxic
prokaryotic stalled ribosome rescue mechanism
- structure & function
transfer-messanger RNA (tmRNA) - combo
- mimics tRNA
Ala
= aminoacyl tRNA synthetase (aaRS) transfers Ala
- middle of tmRNA has short (10aa) peptide used to tag truncated proteins for degradation
Author
chartreuse
ID
289770
Card Set
problems w translation
Description
translation problems
Updated
2014-11-21T05:20:14Z
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